{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:59:54Z","timestamp":1790974794126,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,10,18]],"date-time":"2005-10-18T00:00:00Z","timestamp":1129593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We previously demonstrated high expression of primary\u2010microRNA <jats:italic>BIC<\/jats:italic> (pri\u2010miR\u2010155) in Hodgkin lymphoma (HL) and lack of expression in most non\u2010Hodgkin lymphoma subtypes including some Burkitt lymphoma (BL) cases. Recently, high expression of <jats:italic>BIC<\/jats:italic> was reported in BL in comparison to pediatric leukemia and normal peripheral\u2010blood samples. In this study, we extended our series of BL cases and cell lines to examine expression of <jats:italic>BIC<\/jats:italic> using RNA in situ hybridization (ISH) and quantitative RT\u2010PCR (qRT\u2010PCR) and of miR\u2010155 using Northern blotting. Both <jats:italic>BIC<\/jats:italic> RNA ISH and qRT\u2010PCR revealed no or low levels of <jats:italic>BIC<\/jats:italic> in 25 BL tissue samples [including 7 Epstein\u2013Barr virus (EBV)\u2013positive cases] compared to HL and normal controls. In agreement with these findings, no miR\u2010155 was observed in BL tissues. EBV\u2010negative and EBV latency type I BL cell lines also showed very low <jats:italic>BIC<\/jats:italic> and miR\u2010155 expression levels as compared to HL cell lines. Higher levels of <jats:italic>BIC<\/jats:italic> and miR\u2010155 were detected in in vitro transformed lymphoblastoid EBV latency type III BL cell lines. An association of latency type III infection and induction of <jats:italic>BIC<\/jats:italic> was supported by consistent expression of <jats:italic>BIC<\/jats:italic> in 11 and miR\u2010155 in 2 posttransplantation lymphoproliferative disorder (PTLD) cases. In summary, we demonstrated that expression of <jats:italic>BIC<\/jats:italic> and miR\u2010155 is not a common finding in BL. Expression of <jats:italic>BIC<\/jats:italic> and miR\u2010155 in 3 latency type III EBV\u2013positive BL cell lines and in all primary PTLD cases suggests a possible role for EBV latency type III specific proteins in the induction of <jats:italic>BIC<\/jats:italic> expression. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20273","type":"journal-article","created":{"date-parts":[[2005,10,18]],"date-time":"2005-10-18T16:46:43Z","timestamp":1129654003000},"page":"147-153","source":"Crossref","is-referenced-by-count":184,"title":["Lack of <i>BIC<\/i> and microRNA miR\u2010155 expression in primary cases of Burkitt lymphoma"],"prefix":"10.1002","volume":"45","author":[{"given":"Joost","family":"Kluiver","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Haralambieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"de 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