{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:35:30Z","timestamp":1772753730409,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,3,21]],"date-time":"2006-03-21T00:00:00Z","timestamp":1142899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Near\u2010tetraploidy (82\u201394 chromosomes) makes up fewer than 1% of childhood acute lymphoblastic leukemia (ALL) cases and has been reportedly associated with a possibly poorer prognosis compared with other ploidy groups. We analyzed 783 patients enrolled in the ALL\u2010BFM\u2010Austria 86, \u201090, \u201095, \u201099\/2000 and Interfant\u2010Austria 99 trials in order to assess its incidence, biological characteristics, and prognostic relevance. Twelve of 783 patients (1.5%) had a near\u2010tetraploid ALL. Fluorescence in situ hybridization revealed that eight of the nine B\u2010cell precursor (BCP) cases and none of the three T\u2010cell ALL cases had an <jats:italic>ETV6\/RUNX1<\/jats:italic> rearrangement. After a median follow\u2010up of 11.4 years, none of the patients has relapsed or died. Thus, near\u2010tetraploidy appears to be a specific feature of <jats:italic>ETV6\/RUNX1<\/jats:italic>+ BCP ALL cases that in turn may explain its excellent outcome. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20324","type":"journal-article","created":{"date-parts":[[2006,3,21]],"date-time":"2006-03-21T23:16:40Z","timestamp":1142983000000},"page":"608-611","source":"Crossref","is-referenced-by-count":20,"title":["Near\u2010tetraploidy in childhood B\u2010cell precursor acute lymphoblastic leukemia is a highly specific feature of <i>ETV6\/RUNX1<\/i>\u2010positive leukemic cases"],"prefix":"10.1002","volume":"45","author":[{"given":"Andishe","family":"Attarbaschi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Mann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margit","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael N.","family":"Dworzak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Gadner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oskar A.","family":"Haas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,21]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403471"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04948.x"},{"key":"e_1_2_4_4_1","volume-title":"An international system for human cytogenetic nomenclature","author":"ISCN","year":"1995"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1128"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870040410"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0144"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20222"},{"key":"e_1_2_4_9_1","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1182\/blood.V76.3.590.590","article-title":"Near\u2010triploid and near\u2010tetraploid acute lymphoblastic leukemia of childhood","volume":"76","author":"Pui CH","year":"1990","journal-title":"Blood"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.9.2237.2237"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401506"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401257"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401973"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03958"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403673"},{"key":"e_1_2_4_16_1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1182\/blood.V94.3.1057.415k10_1057_1062","article-title":"Protracted and variable latency of acute lymphoblastic leukemia after TEL\u2013AML1 gene fusion in utero","volume":"94","author":"Wiemels JL","year":"1999","journal-title":"Blood"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.20324","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.20324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T07:06:20Z","timestamp":1697526380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.20324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,21]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1002\/gcc.20324"],"URL":"https:\/\/doi.org\/10.1002\/gcc.20324","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,21]]}}}