{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T14:57:23Z","timestamp":1715957843998},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,11,10]],"date-time":"2006-11-10T00:00:00Z","timestamp":1163116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A large number of nevi (LNN) is a high risk phenotypic trait for developing cutaneous malignant melanoma (CMM). In this study, the breakpoints of a t(9;12)(p21;q13) balanced chromosome translocation were finely mapped in a family with LNN and CMM. Molecular characterization of the 9p21 breakpoint identified a novel gene <jats:italic>C9orf14<\/jats:italic> expressed in melanocytes disrupted by the translocation. Integrative analysis of functional genomics data was applied to determine the role of <jats:italic>C9orf14<\/jats:italic> in CMM development. An analysis of genome\u2010wide DNA copy number alterations in melanoma tumors revealed the loss of the <jats:italic>C9orf14<\/jats:italic> locus, located proximal to <jats:italic>CDKN2A<\/jats:italic>, in approximately one\u2010fourth of tumors. Analysis of gene expression data in cancer cell lines and melanoma tumors suggests a loss of <jats:italic>C9orf14<\/jats:italic> expression in melanoma tumorigenesis. Taken together, our results indicate that <jats:italic>C9orf14<\/jats:italic> is a candidate tumor\u2010suppressor for nevus development and late stage melanoma at 9p21, a region frequently deleted in different types of human cancers. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20396","type":"journal-article","created":{"date-parts":[[2006,11,10]],"date-time":"2006-11-10T16:46:54Z","timestamp":1163177214000},"page":"155-162","source":"Crossref","is-referenced-by-count":8,"title":["Molecular characterization of a t(9;12)(p21;q13) balanced chromosome translocation in combination with integrative genomics analysis identifies <i>C9orf14<\/i> as a candidate tumor\u2010suppressor"],"prefix":"10.1002","volume":"46","author":[{"given":"Miguel 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