{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:09:42Z","timestamp":1792008582732,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T00:00:00Z","timestamp":1166054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The importance of somatic <jats:italic>TP53<\/jats:italic> mutations and germline <jats:italic>TP53<\/jats:italic> codon 72 genotype in the survival of women with epithelial ovarian cancer is controversial. Recent data suggest that a promoter polymorphism in the <jats:italic>MDM2<\/jats:italic> gene may influence age of cancer onset in a gender\u2010specific fashion. We sought to determine the relationship between somatic <jats:italic>TP53<\/jats:italic> mutations, germline genotypes at <jats:italic>TP53<\/jats:italic> codon 72 and <jats:italic>MDM2<\/jats:italic> SNP309, and overall survival and response to chemotherapy in a large series of patients with ovarian and peritoneal carcinomas. Of the 188 cancers, 103 (54.8%) had a <jats:italic>TP53<\/jats:italic> mutation, of which 71% were missense mutations and 29% were null mutations. <jats:italic>TP53<\/jats:italic> mutation status and mutation type (null vs. missense) did not influence response to therapy or overall survival. Women with the codon 72 Pro\/Pro had a decreased overall survival (median, 29 months) compared with women with one or two arginine alleles (median, 49 months; <jats:italic>P<\/jats:italic> = 0.04). Somatic mutation or deletion was equally common for either codon 72 allele. Age of diagnosis was not influenced by codon 72 but showed a trend for younger age in women with somatic <jats:italic>TP53<\/jats:italic> mutations and the <jats:italic>MDM2<\/jats:italic> G\/G genotype. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20407","type":"journal-article","created":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T22:47:51Z","timestamp":1166136471000},"page":"239-247","source":"Crossref","is-referenced-by-count":42,"title":["Common polymorphisms in <i>TP53<\/i> and <i>MDM2<\/i> and the relationship to <i>TP53<\/i> mutations and clinical outcomes in women with ovarian and peritoneal carcinomas"],"prefix":"10.1002","volume":"46","author":[{"given":"Vijaya","family":"Galic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Willner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Wollan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rochelle","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Goff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi J.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth 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