{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:00:24Z","timestamp":1791234024466,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:00:00Z","timestamp":1172793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fusion of the CREB regulated transcription coactivator CRTC1 (a.k.a. MECT1, TORC1, or WAMTP1) to the Notch coactivator MAML2 is a characteristic feature of low\u2010grade mucoepidermoid carcinomas of salivary and bronchial glands. The CRTC1\u2013MAML2 fusion protein acts by inducing transcription of cAMP\/CREB target genes, and this activity is crucial for the transforming properties of the protein. Here we show that the <jats:italic>CRTC1<\/jats:italic>\u2013<jats:italic>MAML2<\/jats:italic> gene fusion is also frequent in benign hidradenomas of the skin. FISH and RT\u2010PCR analyses revealed that hidradenomas are genetically heterogeneous, and that 10 of the 20 tumors analyzed (50%) contained the <jats:italic>CRTC1<\/jats:italic>\u2013<jats:italic>MAML2<\/jats:italic> gene fusion and expressed the resulting fusion transcript. Immunohistochemical analysis demonstrated expression of the fusion protein in the majority of tumor cells, including clear cells, poroid cells, and cells with epidermoid and ductal differentiation. In addition, we could show that all fusion\u2010positive tumors were morphologically distinguished by the presence of more or less abundant areas of clear cells whereas all fusion\u2010negative tumors lacked clear cells. Our findings thus demonstrate that the <jats:italic>CRTC1<\/jats:italic>\u2013<jats:italic>MAML2<\/jats:italic> gene fusion is frequent in hidradenomas and is associated with clear cell variants of this tumor. Taken together, the present and previous observations indicate that the <jats:italic>CRTC1<\/jats:italic>\u2013<jats:italic>MAML2<\/jats:italic> fusion is etiologically linked to benign and low\u2010grade malignant tumors originating from diverse exocrine glands rather than being linked to a separate tumor entity. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20440","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T19:22:38Z","timestamp":1172863358000},"page":"559-563","source":"Crossref","is-referenced-by-count":99,"title":["Frequent fusion of the <i>CRTC1<\/i> and <i>MAML2<\/i> genes in clear cell variants of cutaneous hidradenomas"],"prefix":"10.1002","volume":"46","author":[{"given":"Marta","family":"Winnes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"M\u00f6lne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart","family":"Suurk\u00fcla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ywonne","family":"Andr\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Persson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Enlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Stenman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,2]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"311","volume-title":"Neoplasms with Eccrine Differentiation","author":"Abenoza P","year":"1990"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20306"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20168"},{"key":"e_1_2_5_5_1","first-page":"1589","volume-title":"Pathology of the Skin with Clinical Correlations","author":"Brenn T","year":"2005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90131-8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1125"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2003.09.007"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199708000-00006"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(94)90144-9"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-80126-6"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209627"},{"key":"e_1_2_5_13_1","first-page":"351","volume-title":"Human Embryology","author":"Larsen WJ","year":"2001"},{"key":"e_1_2_5_14_1","first-page":"1565","article-title":"A human adenolymphoma showing the chromosomal aberrations del (7)(p12p14\u201015) and t(11;19)(q21;p12\u201013)","volume":"9","author":"Mark J","year":"1989","journal-title":"Anticancer Res"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(94)90001-9"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2376"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000147397.08853.6f"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2005.01.002"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1083"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2006.060020"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600719"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.20440","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.20440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T01:17:58Z","timestamp":1695950278000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.20440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,2]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1002\/gcc.20440"],"URL":"https:\/\/doi.org\/10.1002\/gcc.20440","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,2]]}}}