{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T13:46:01Z","timestamp":1744292761932},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,5,10]],"date-time":"2007-05-10T00:00:00Z","timestamp":1178755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Approximately 70% of gastric mucosa\u2010associated lymphoid tissue (MALT) lymphomas can be successfully treated with <jats:italic>H. pylori<\/jats:italic> eradication. The translocation t(11;18)(q21;q21) characteristic of MALT lymphoma is recognized as a marker for <jats:italic>H. pylori<\/jats:italic> independency, but this marker is found in only a half of the MALT lymphomas resistant to <jats:italic>H. pylori<\/jats:italic> eradication. Detailed analyses of the genomic features of eradication resistant as well as responsive groups are important for understanding their molecular basis. We performed array\u2010based comparative genomic hybridization (array\u2010CGH) for 29 gastric MALT lymphomas treated with <jats:italic>H. pylori<\/jats:italic> eradication. These comprised ten cases of t(11;18) positive MALT, nine cases of t(11;18) negative MALT with <jats:italic>H. pylori<\/jats:italic> dependency, and ten cases of t(11;18) negative MALT with <jats:italic>H. pylori<\/jats:italic> independency. Array\u2010CGH analysis demonstrated that no significant genetic alterations were found in t(11;18) positive MALT lymphomas, but numerous genomic alterations were detected in t(11;18) negative MALT lymphomas. Many of these alterations were similar to those found in diffuse large B\u2010cell lymphoma with trisomy 3 being the most recurrent alteration. Within the t(11;18) negative MALT lymphoma without large cell components group, genomic imbalances occurred more frequently in the <jats:italic>H. pylori<\/jats:italic> independent than in the <jats:italic>H. pylori<\/jats:italic> dependent group (<jats:italic>P<\/jats:italic> = 0.02). Genomic imbalances are associated with <jats:italic>H. pylori<\/jats:italic> independency in t(11;18) negative gastric MALT lymphomas. They may thus play an important role in the development of <jats:italic>H. pylori<\/jats:italic> independency. This article contains Supplementary Material available at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.interscience.wiley.com\/jpages\/1045-2257\/suppmat\">http:\/\/www.interscience.wiley.com\/jpages\/1045\u20102257\/suppmat<\/jats:ext-link>. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20464","type":"journal-article","created":{"date-parts":[[2007,5,10]],"date-time":"2007-05-10T19:47:13Z","timestamp":1178826433000},"page":"784-790","source":"Crossref","is-referenced-by-count":23,"title":["Chromosomal imbalances are associated with outcome of <i>Helicobacter pylori<\/i> eradication in t(11;18)(q21;q21) negative gastric mucosa\u2010associated lymphoid tissue lymphomas"],"prefix":"10.1002","volume":"46","author":[{"given":"Noriko","family":"Fukuhara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuneya","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Yatabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Morishima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Seto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203018"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1182\/blood.V95.12.4014","article-title":"Translocation 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