{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:14:59Z","timestamp":1759580099354},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,7,18]],"date-time":"2007-07-18T00:00:00Z","timestamp":1184716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Reciprocal translocations involving the immunoglobulin loci and the cellular oncogene<jats:italic>MYC<\/jats:italic>are hallmark mutations of the human postgerminal center B cell neoplasm, Burkitt's lymphoma. They are occasionally found in other B cell lymphomas, as well. Translocations involving the heavy chain locus (<jats:italic>IGH<\/jats:italic>) place the<jats:italic>MYC<\/jats:italic>gene either in cis with both the intronic enhancer E\u03bc and the<jats:italic>IGH<\/jats:italic>3\u2032 regulatory region (3\u2032RR) or in cis with only the 3\u2032RR. The result is deregulated<jats:italic>MYC<\/jats:italic>expression. Recent studies have led to some controversy as to when, during B lymphocyte development,<jats:italic>IGH\/MYC<\/jats:italic>chromosome translocations take place. A related issue, relevant not only to lymphoma development but also to normal controls on<jats:italic>IGH<\/jats:italic>gene expression, is the stage, during B lymphocyte development, at which the 3\u2032RR is capable of activating<jats:italic>MYC<\/jats:italic>expression. We have developed mice transgenic for a human<jats:italic>MYC<\/jats:italic>(h<jats:italic>MYC<\/jats:italic>) gene under control of the four core enhancers from the mouse<jats:italic>Igh<\/jats:italic>3\u2032RR. Unlike other transgenic mouse models where premature and inappropriate MYC expression disrupts normal B cell development, the h<jats:italic>MYC<\/jats:italic>transgene in these studies carries a mutation that prohibits MYC protein synthesis. As a result, h<jats:italic>MYC<\/jats:italic>expression can be analyzed in all of the normal B cell compartments. Our data show that h<jats:italic>MYC<\/jats:italic>is expressed almost exclusively in B\u2010lineage cells and is induced to high levels as soon as bone marrow cells reach the immature B cell stage. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20480","type":"journal-article","created":{"date-parts":[[2007,7,18]],"date-time":"2007-07-18T20:16:19Z","timestamp":1184789779000},"page":"950-959","source":"Crossref","is-referenced-by-count":15,"title":["In a model of immunoglobulin heavy\u2010chain (<i>IGH<\/i>)\/<i>MYC<\/i>translocation, the<i>Igh<\/i>3\u2032 regulatory region induces<i>MYC<\/i>expression at the immature stage of B cell development"],"prefix":"10.1002","volume":"46","author":[{"given":"Yi","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung 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