{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:55:22Z","timestamp":1790006122885,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,8,15]],"date-time":"2007-08-15T00:00:00Z","timestamp":1187136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Very few recurrent chromosomal abnormalities have been identified in T\u2010cell non\u2010Hodgkin lymphomas. These involve the <jats:italic>TRA@\/TRD@<\/jats:italic> gene at chromosome band 14q11 in up to 15% of cases. We recently reported a novel and recurrent translocation, t(14;19)(q11;q13), in peripheral T\u2010cell lymphoma (PTCL). Fluorescence in situ hybridization analysis performed in three cases suggested an involvement of the <jats:italic>TRA@\/TRD@<\/jats:italic> locus at 14q11 and of a region telomeric to <jats:italic>BCL3<\/jats:italic> on 19q13. We now report the molecular cloning of these translocations. Sequence analysis confirmed the involvement of the <jats:italic>TRA@\/TRD@<\/jats:italic> and indicated that the breakpoints were located mainly in the <jats:italic>TRAJ<\/jats:italic> region. On chromosome 19, our results revealed a new clustering of breakpoints outside the region involved in t(14;19)(q32;q13)\u2010positive B\u2010cell malignancies. Remarkably, all three breaks were located downstream or within the <jats:italic>PVRL2<\/jats:italic> gene, in a small 10.3 kb interval, suggesting a nonrandom location of the breakpoints. For two patients, a high mRNA expression of both <jats:italic>PVRL2<\/jats:italic> and <jats:italic>BCL3<\/jats:italic> was found. In conclusion, we identified <jats:italic>PVRL2<\/jats:italic> as a new recurrent partner gene of the <jats:italic>TRA@<\/jats:italic> locus in PTCL. These results suggest that both <jats:italic>BCL3<\/jats:italic> and <jats:italic>PVRL2<\/jats:italic> may participate in the pathogenesis of these PTCLs, but further studies should be undertaken to investigate the precise role of these genes. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20490","type":"journal-article","created":{"date-parts":[[2007,8,15]],"date-time":"2007-08-15T16:16:27Z","timestamp":1187194587000},"page":"1011-1018","source":"Crossref","is-referenced-by-count":31,"title":["<i>PVRL2<\/i> is translocated to the <i>TRA<\/i>@ locus in t(14;19)(q11;q13)\u2010positive peripheral T\u2010cell lymphomas"],"prefix":"10.1002","volume":"46","author":[{"given":"Carole","family":"Almire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bertrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Ruminy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Maingonnat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Wlodarska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 I.","family":"Mart\u00edn\u2010Subero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Siebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Tilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Bastard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-041012"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20562"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404529"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1139\/o03-051"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800140"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-010835"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402884"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2005.00539.x"},{"key":"e_1_2_5_10_1","volume-title":"World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_5_11_1","first-page":"383","article-title":"Central genetic alterations common to all HCV\u2010positive, HBV\u2010positive and non\u2010B, non\u2010C hepatocellular carcinoma: A new approach to identify novel tumor markers","volume":"28","author":"Kurokawa Y","year":"2006","journal-title":"Int J Oncol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062041"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(99)00151-X"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.12.4602"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3843"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404695"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3620"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199709)20:1<64::AID-GCC10>3.0.CO;2-F"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(96)00247-6"},{"key":"e_1_2_5_20_1","unstructured":"Mitelman F editor.1995.An International System for Human Cytogenetic Nomenclature (1995): Recommendations of the International Standing Committee on Human Cytogenetic Nomenclature Memphis Tennessee October 1994. Basel Switzeland: S. Karger."},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2003.01544.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/372143a0"},{"key":"e_1_2_5_23_1","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1182\/blood.V90.3.1233","article-title":"A chromosome 14q11\/TCR \u03b1\/\u03b4 specific yeast artificial chromosome improves the detection rate and characterization of chromosome abnormalities in T\u2010lymphoproliferative disorders","volume":"90","author":"Rack KA","year":"1997","journal-title":"Blood"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10299"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.2.505.505"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.09.025"},{"key":"e_1_2_5_27_1","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.4049\/jimmunol.158.3.1208","article-title":"Preferential rearrangements of the T cell receptor\u2010\u03b4\u2010deleting elements in human T cells","volume":"158","author":"Verschuren MC","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_5_28_1","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1182\/blood.V90.6.2456","article-title":"Rapid molecular cloning of rearrangements of the IGHJ locus using long\u2010distance inverse polymerase chain reaction","volume":"90","author":"Willis TG","year":"1997","journal-title":"Blood"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.20490","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.20490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T12:53:01Z","timestamp":1697460781000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.20490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,15]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1002\/gcc.20490"],"URL":"https:\/\/doi.org\/10.1002\/gcc.20490","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,15]]}}}