{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:47:05Z","timestamp":1790740025803,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,9,20]],"date-time":"2007-09-20T00:00:00Z","timestamp":1190246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The genomic aberrations in extra nodal marginal zone B cell lymphoma vary according to their anatomical origin. This polarization is a reflection of the participation of different genes in the lymphomagenesis of marginal zone B cell lymphoma. We previously demonstrated by means of genome\u2010wide array comparative genomic hybridization (CGH) that the genomic profile of ocular adnexal marginal zone B cell lymphoma is distinct from that of pulmonary or nodal marginal zone B cell lymphoma. The novel finding was a recurrent deletion of a 2.9\u2010Mb region at chromosome band 6q23.3\u2010q24.1, including homozygous loss, in ocular adnexal marginal zone B cell lymphoma. For a more detailed examination of the deletions of 6q23.3\u201024.1, we used contig bacterial artificial chromosome (BAC) array CGH, containing 24 BAC clones covering the 2.9\u2010Mb region, to analyze nine cases with 6q23.3\u2010q24.1 loss. We narrowed the minimal common region down to a length of 586 kb with two genes and four expressed sequence tags (ESTs). All of these genes and ESTs were subjected to RT\u2010PCR and real\u2010time quantitative RT\u2010PCR. Correlation between genomic loss and expression level was found only for <jats:italic>TNFAIP3<\/jats:italic>, demonstrating that <jats:italic>TNFAIP3<\/jats:italic> is a target gene of 6q deletion in ocular adnexal marginal zone B cell lymphoma. <jats:italic>TNFAIP3<\/jats:italic> is an inhibitor of NF\u2010kB signaling so that loss of this gene may play an important role in lymphomagenesis and suggests that <jats:italic>TNFAIP3<\/jats:italic> may act as a tumor suppressor gene in ocular adnexal marginal zone B cell lymphoma. This article contains Supplementary Material available at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.interscience.wiley.com\/jpages\/1045-2257\/suppmat\">http:\/\/www.interscience.wiley.com\/jpages\/1045\u20102257\/suppmat<\/jats:ext-link>. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20499","type":"journal-article","created":{"date-parts":[[2007,9,20]],"date-time":"2007-09-20T15:46:24Z","timestamp":1190303184000},"page":"1-7","source":"Crossref","is-referenced-by-count":74,"title":["<i>TNFAIP3<\/i> is the target gene of chromosome band 6q23.3\u2010q24.1 loss in ocular adnexal marginal zone B cell lymphoma"],"prefix":"10.1002","volume":"47","author":[{"given":"Keiichiro","family":"Honma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinobu","family":"Tsuzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivasundaram","family":"Karnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifusa","family":"Aizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won 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