{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:44:16Z","timestamp":1758631456167},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,2,29]],"date-time":"2008-02-29T00:00:00Z","timestamp":1204243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In vivo response to initial therapy, as assessed by determination of minimal residual disease (MRD) after 5 and 12 weeks of treatment, has evolved as a strong prognostic factor in children with acute lymphoblastic leukemia (ALL) treated according to the BFM regime. Individual treatment response may be influenced by copy number alterations (CNA) leading to altered gene expression. We aimed to evaluate CNA using high\u2010resolution array\u2010comparative genomic hybridization (array\u2010CGH) in different treatment\u2010response groups. Leukemic genomic profiles of 25 standard risk (MRD\u2010SR) and 25 high risk (MRD\u2010HR) patients were compared. CNAs were found in 46\/50 patients (92%). The most significant difference was a gain of 1q23\u2010qter because of an unbalanced t(1;19), found in 10\/25 MRD\u2010SR patients, but in none of the MRD\u2010HR patients (<jats:italic>P<\/jats:italic> &lt; 0.001). The most frequent CNAs in the MRD\u2010HR group were deletions of genomic regions harboring the immunoglobulin genes (<jats:italic>Ig<\/jats:italic>), e.g., 2p11.2 in 60% of MRD\u2010HR compared to 28% of MRD\u2010SR (<jats:italic>P<\/jats:italic> = 0.045). Combining all <jats:italic>Ig<\/jats:italic> loci, significantly more MRD\u2010HR than MRD\u2010SR patients displayed deletions (17:8 patients, <jats:italic>P<\/jats:italic> = 0.02). Frequency of other CNAs, such as loss of 9p21 or gains of 21q, did not differ strongly between the two patient groups. This is the first study evaluating the clinical significance of CNA as detected by array\u2010CGH in childhood ALL and the first to suggest that such analyses may provide clinically important data. This article contains supplementary material available via the Internet at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.interscience.wiley.com\/jpages\/1045-2257\/suppmat\">http:\/\/www.interscience.wiley.com\/jpages\/1045\u20102257\/suppmat<\/jats:ext-link>. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20557","type":"journal-article","created":{"date-parts":[[2008,2,29]],"date-time":"2008-02-29T21:16:21Z","timestamp":1204319781000},"page":"471-480","source":"Crossref","is-referenced-by-count":17,"title":["Copy number alterations in childhood acute lymphoblastic leukemia and their association with minimal residual disease"],"prefix":"10.1002","volume":"47","author":[{"given":"Doris","family":"Steinemann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Cario","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Stanulla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonid","family":"Karawajew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Tauscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Weigmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gudrun","family":"G\u00f6hring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolf\u2010Dieter","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Harbott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Radlwimmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Bartram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Lichter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Schrappe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Schlegelberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,2,29]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1783","article-title":"Proposals for the immunological classification of acute leukemias. 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