{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:06:12Z","timestamp":1791104772732,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,7,9]],"date-time":"2008-07-09T00:00:00Z","timestamp":1215561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Approximately 25,000 ovarian cancers are diagnosed in the US annually, and 75% of cases are in the advanced stage when they are largely incurable. There is a critical need for improved early detection tools and development of novel treatments. Because chromosome band 20q13 is a commonly DNA amplified region in ovarian cancer and increase in 20q13 copy number may be an early event, we examined the DNA amplification and RNA expression pattern of 239 microarray probes mapping to this region with the goal of identifying gene(s) associated with ovarian cancer. Using Agilent expression microarray analysis and FISH to tumor tissue arrays, we narrowed the candidates to 19 genes that were consistently overexpressed in a subset of tumors amplified for both <jats:italic>ZNF217<\/jats:italic> and <jats:italic>TPD54<\/jats:italic>, although, interestingly the candidates do not include these two amplified genes. Unsupervised clustering of 225 ovarian samples with respect to RNA expression of these 19 genes allowed identification of a 20q\u2010amplified subset of 51 (23%) tumors and this subset was significantly correlated with poor outcome. Of the 19 candidate genes in this subset, <jats:italic>ADRM1<\/jats:italic> overexpression was the most highly correlated with amplification, was amplified in a higher percentage of tumors than <jats:italic>ZNF217<\/jats:italic> and <jats:italic>TPD54<\/jats:italic>, and was significantly upregulated with respect to stage, recurrence and metastasis. In addition, overexpression of <jats:italic>ADRM1<\/jats:italic> correlates significantly with shorter time to recurrence and overall survival. Functional analysis is now warranted to determine whether <jats:italic>ADRM1<\/jats:italic> is a target for early screening and\/or therapy for ovarian cancer. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20592","type":"journal-article","created":{"date-parts":[[2008,7,9]],"date-time":"2008-07-09T18:07:03Z","timestamp":1215626823000},"page":"873-883","source":"Crossref","is-referenced-by-count":44,"title":["Comprehensive analysis of 20q13 genes in ovarian cancer identifies <i>ADRM1<\/i> as amplification target"],"prefix":"10.1002","volume":"47","author":[{"given":"Marlena 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