{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:13:09Z","timestamp":1791047589925,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T00:00:00Z","timestamp":1217203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Breast cancer accounts for over 20% of all female cancers. A positive family history remains one of the most important risk factors for the disease, with first\u2010degree relatives of patients having a twofold elevated risk. Known breast cancer susceptibility genes such as <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> explain only 20\u201325% of this risk, suggesting the existence of other breast cancer susceptibility genes. Here, we report the results of a genome\u2010wide linkage scan in 55 high\u2010risk Dutch breast cancer families with no mutations in <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic>. Twenty\u2010two of these families were also part of a previous linkage study by the Breast Cancer Linkage Consortium. In addition, we performed CGH analyses in 61 tumors of these families and 31 sporadic tumors. Three regions were identified with parametric HLOD scores &gt;1, and three with nonparametric LOD scores &gt;1.5. Upon further marker genotyping for the candidate loci, and the addition of another 30 families to the analysis, only the locus on chromosome 9 (9q21\u201022, marker <jats:italic>D9S167<\/jats:italic>) remained significant, with a nonparametric multipoint LOD score of 3.96 (parametric HLOD 0.56, \u03b1 = 0.18). With CGH analyses we observed preferential copy number loss at BAC RP11\u2010276H19, containing <jats:italic>D9S167<\/jats:italic> in familial tumors as compared to sporadic tumors (<jats:italic>P<\/jats:italic> &lt; 0.001). Five candidate genes were selected from the region around <jats:italic>D9S167<\/jats:italic> and their coding regions subjected to direct sequence analysis in 16 probands. No clear pathogenic mutations were found in any of these genes. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20597","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T18:34:18Z","timestamp":1217270058000},"page":"947-956","source":"Crossref","is-referenced-by-count":16,"title":["Genome\u2010wide linkage scan in Dutch hereditary non\u2010BRCA1\/2 breast cancer families identifies 9q21\u201022 as a putative breast cancer susceptibility locus"],"prefix":"10.1002","volume":"47","author":[{"given":"Rogier A.","family":"Oldenburg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin H. G.","family":"Kroeze\u2010Jansema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanine J.","family":"Houwing\u2010Duistermaat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Bayley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Dambrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christi J.","family":"van Asperen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ans M. W.","family":"van den Ouweland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik H.","family":"van Beers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra M.","family":"Nederlof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Vasen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoline","family":"Hoogerbrugge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cees J.","family":"Cornelisse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Meijers\u2010Heijboer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Devilee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng786"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.10261"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20405"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10204"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.10.009"},{"key":"e_1_2_6_9_1","first-page":"232","article-title":"Genetic 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