{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:32:05Z","timestamp":1766269925936},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T00:00:00Z","timestamp":1217203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The etiology of mycosis fungoides (MF), the most frequent form of cutaneous T cell lymphoma (CTCL), is poorly understood. No specific genetic aberration has been detected, especially in early\u2010stage disease, possibly due to the clinical and histological heterogeneity of patient series and to the different sources of malignant cells (skin, blood, or lymph node) included in most studies. Frozen skin biopsies from 16 patients with early\u2010stage MF were studied using array\u2010based comparative genomic hybridization. A DNA pool from healthy donors was used as the reference. Results demonstrated recurrent loss of 19, 7p22.1\u2010p22.3, 7q11.1\u2010q11.23, 9q34.12, 12q24.31, and 16q22.3\u2010q23.1, and gain of 8q22.3\u2010q23.1 and 21q22.12. The 12q24.31 region was recurrently deleted in 7\/16 patients. Real\u2010time PCR investigation for deletion of genes <jats:italic>BCL7A, SMAC\/DIABLO,<\/jats:italic> and <jats:italic>RHOF\u2014<\/jats:italic>three tumor suppressor genes with a putative role in hematological malignancies\u2014demonstrated that they were deleted in 9, 10, and 13 cases, respectively. The identified genomic alterations and individual genes could yield important insights into the early steps of MF pathogenesis. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20601","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T18:35:18Z","timestamp":1217270118000},"page":"1067-1075","source":"Crossref","is-referenced-by-count":53,"title":["Array\u2010based comparative genomic hybridization in early\u2010stage mycosis fungoides: Recurrent deletion of tumor suppressor genes <i>BCL7A, SMAC\/DIABLO<\/i>, and 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