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For this purpose, we used array\u2010based intermediate\u2010high resolution genomic profiling in combination with Affymetrix\u2122 gene expression analysis. Tumor specimens from 128 FL patients were analyzed for the presence of genomic aberrations and the results were correlated to clinical data sets and mRNA expression levels. In 114 (89%) of the 128 analyzed cases, a total of 688 genomic aberrations (384 gains\/amplifications and 304 losses) were detected. Frequent genomic aberrations were: \u22121p36 (18%), +2p15 (24%), \u22123q (14%), \u22126q (25%), +7p (19%), +7q (23%), +8q (14%), \u22129p (16%), \u221211q (15%), +12q (20%), \u221213q (11%), \u221217p (16%), +18p (18%), and +18q (28%). Critical segments of these imbalances were delineated to genomic fragments with a minimum size down to 0.2 Mb. By comparison of these with mRNA gene expression data, putative candidate genes were identified. Moreover, we found that deletions affecting the tumor suppressor gene <jats:italic>CDKN2A\/B<\/jats:italic> on 9p21 were detected in nontransformed FL grade I\u2013II. For this aberration as well as for \u22126q25 and \u22126q26, an association with inferior survival was observed. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20617","type":"journal-article","created":{"date-parts":[[2008,9,30]],"date-time":"2008-09-30T19:01:14Z","timestamp":1222801274000},"page":"39-54","source":"Crossref","is-referenced-by-count":68,"title":["Microarray\u2010based genomic profiling reveals novel genomic aberrations in follicular lymphoma which associate with patient survival and gene expression status"],"prefix":"10.1002","volume":"48","author":[{"given":"Carsten","family":"Schwaenen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Viardot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilmar","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F. 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