{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:15:36Z","timestamp":1792880136287,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,11,3]],"date-time":"2008-11-03T00:00:00Z","timestamp":1225670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An overexpression of <jats:italic>HMGA2<\/jats:italic> is supposed to be a key event in the genesis of leiomyoma with chromosomal rearrangements affecting the region 12q14\u201015 targeting the <jats:italic>HMGA2<\/jats:italic> gene, but gene expression data regarding differences between uterine leiomyomas with and those without 12q14\u201015 aberrations are insufficient. To address the question whether <jats:italic>HMGA2<\/jats:italic> is only upregulated in the 12q14\u201015 subgroup, the expression of <jats:italic>HMGA2<\/jats:italic> was analyzed in a comprehensive set of leiomyomas (<jats:italic>n<\/jats:italic> = 180) including tumors with 12q14\u201015 chromosomal aberrations (<jats:italic>n<\/jats:italic> = 13) and matching myometrial tissues (<jats:italic>n<\/jats:italic> = 51) by quantitative RT\u2010PCR. The highest expression levels for <jats:italic>HMGA2<\/jats:italic> were observed in tumors with rearrangements affecting the region 12q14\u201015, but although <jats:italic>HMGA2<\/jats:italic> is expressed at lower levels in leiomyomas without such aberrations, the comparison between the expression in myomas and matching myometrial tissues indicates a general upregulation of <jats:italic>HMGA2<\/jats:italic> regardless of the presence or absence of such chromosomal abnormalities. The significant (<jats:italic>P<\/jats:italic> &lt; 0.05) overexpression of <jats:italic>HMGA2<\/jats:italic> also in the group of fibroids without chromosomal aberrations of the 12q14\u201015 region suggests a general role of <jats:italic>HMGA2<\/jats:italic> in the development of the disease. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20627","type":"journal-article","created":{"date-parts":[[2008,11,3]],"date-time":"2008-11-03T16:32:24Z","timestamp":1225729944000},"page":"171-178","source":"Crossref","is-referenced-by-count":61,"title":["Overexpression of <i>HMGA2<\/i> in uterine leiomyomas points to its general role for the pathogenesis of the disease"],"prefix":"10.1002","volume":"48","author":[{"given":"Markus","family":"Klemke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maliheh 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