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However, in most of the cases, the amplified region is not restricted to the <jats:italic>MLL<\/jats:italic> locus. In this study, we investigated 19 patients with AML\/MDS and <jats:italic>MLL<\/jats:italic> gain\/amplification. By means of array CGH performed in 12 patients, we were able to delineate the minimal deleted regions within 5q and 17p and identified three independent regions 11q\/I\u2010III that were amplified in all cases. Gene expression profiles established in 15 cases were used to identify candidate genes within these regions. Notably, analysis of our data suggests a correlation of loss of 5q and 17p and expression of genes present in 11q23\u201025. Furthermore, we demonstrate that the gene expression signature can be used to discriminate AML\/MDS with <jats:italic>MLL<\/jats:italic> amplification from several other types of AML. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20658","type":"journal-article","created":{"date-parts":[[2009,3,20]],"date-time":"2009-03-20T19:17:44Z","timestamp":1237576664000},"page":"510-520","source":"Crossref","is-referenced-by-count":25,"title":["AML\/MDS with 11q\/<i>MLL<\/i> amplification show characteristic gene expression signature and interplay of DNA copy number 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