{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:56:13Z","timestamp":1763765773802},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T00:00:00Z","timestamp":1242172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ovarian cancer cells exhibit complex karyotypic alterations causing deregulation of numerous genes. Some of these genes are probably causal for cancer formation and local growth, whereas others are causal for metastasis and recurrence. By using publicly available data sets, we have investigated the relation of gene expression and chromosomal position to identify chromosomal regions of importance for early recurrence of ovarian cancer. By use of \u201cGene Set Enrichment Analysis,\u201d we have ranked chromosomal regions according to their association to survival. Over\u2010representation analysis including 1\u20134 consecutive cytogenetic bands identified regions with increased expression for chromosome 5q12\u201014, and a very large region of chromosome 7 with the strongest signal at 7p15\u201013 among tumors from short\u2010living patients. Reduced gene expression was identified at 4q26\u201032, 6p12\u2010q15, 9p21\u2010q32, and 11p14\u201011. We summarized mutation load in these regions by a combined mutation score that is statistical significantly associated to survival by analysis in the data sets used for identification of the regions. Furthermore, the prognostic value of the combined mutation score was validated in an independent large data set using death (<jats:italic>P<\/jats:italic> = 0.015) and recurrence (<jats:italic>P<\/jats:italic> = 0.002) as outcome. The combined mutation score is strongly associated to upregulation of several growth factor pathways. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20676","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T19:34:26Z","timestamp":1242243266000},"page":"711-724","source":"Crossref","is-referenced-by-count":11,"title":["Gene expression meta\u2010analysis identifies chromosomal regions involved in ovarian cancer survival"],"prefix":"10.1002","volume":"48","author":[{"given":"Mads","family":"Thomassen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten M.","family":"Jochumsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole","family":"Mogensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qihua","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torben A.","family":"Kruse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,5,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000192407.04428.bb"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.04760"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04296"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.0795"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701824551"},{"key":"e_1_2_6_7_1","first-page":"1271","article-title":"Loss of heterozygosity at chromosome 9q22\u201031 is a frequent and early event in ovarian tumors","volume":"24","author":"Byrom J","year":"2004","journal-title":"Int J Oncol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.03.051"},{"key":"e_1_2_6_9_1","first-page":"95","article-title":"Allele loss on chromosome 11p is associated with poor survival in ovarian cancer","volume":"10","author":"Eccles DM","year":"1992","journal-title":"Dis Markers"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22301.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1995.340"},{"key":"e_1_2_6_12_1","first-page":"2166","article-title":"Allelic loss of 16q23.2\u201024.2 is an independent marker of good prognosis in primary breast cancer","volume":"58","author":"Hansen LL","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-1673"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3694"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327480701400312"},{"key":"e_1_2_6_16_1","article-title":"Gene expression profiles as a prognostic marker in woman with ovarian cancer","author":"Jochumsen J","journal-title":"Int J Gynecol Cancer"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-07-0111"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199709039037"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-5576(97)00061-0"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-2110"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2008.01.001"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1681"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-006-0054-4"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/284067a0"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602941"},{"key":"e_1_2_6_26_1","first-page":"209","article-title":"Association of chromosome 7, chromosome 10 and EGFR gene amplification in glioblastoma multiforme","volume":"24","author":"Lopez\u2010Gines C","year":"2005","journal-title":"Clin Neuropathol"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2366"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2005.06.023"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20053"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(96)00169-0"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-3907"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.034389"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.04.070"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20356"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2264(2000)9999:9999<::AID-GCC1010>3.0.CO;2-1"},{"key":"e_1_2_6_37_1","first-page":"5382","article-title":"An approach to analysis of large\u2010scale correlations between genome changes and clinical endpoints in ovarian cancer","volume":"60","author":"Suzuki S","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc0934"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-008-0038-x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0196"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20392"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10029"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.20676","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.20676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T14:53:25Z","timestamp":1695912805000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.20676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,13]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["10.1002\/gcc.20676"],"URL":"https:\/\/doi.org\/10.1002\/gcc.20676","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,13]]}}}