{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:21:56Z","timestamp":1791037316521,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T00:00:00Z","timestamp":1243555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adult T\u2010cell leukemia\/lymphoma (ATLL) is a malignant tumor caused by latent human T\u2010lymphotropic virus 1 (HTLV\u20101) infection. We previously identified a common breakpoint cluster region at 10p11.2 in acute\u2010type ATLL by spectral karyotyping. Single nucleotide polymorphism array comparative genomic hybridization analysis of the breakpoint region in three ATLL\u2010related cell lines and four patient samples revealed that the chromosomal breakpoints are localized within the enhancer of polycomb 1 (<jats:italic>EPC1<\/jats:italic>) gene locus in an ATLL\u2010derived cell line (SO4) and in one patient with acute\u2010type ATLL. <jats:italic>EPC1<\/jats:italic> is a human homologue of the E(Pc) enhancer of polycomb gene of <jats:italic>Drosophila<\/jats:italic>. Inappropriate expression of the polycomb group gene family has been linked to the loss of normal gene silencing pathways, which can contribute to the loss of cell identity and malignant transformation in many kinds of cancers. In the case of the SO4 cell line, which carried a der(10)t(2;10)(p23;p11.2) translocation, <jats:italic>EPC1<\/jats:italic> was fused with the additional sex combs\u2010like 2 (<jats:italic>ASXL2<\/jats:italic>) gene at 2p23.3 (<jats:italic>EPC1\/ASXL2<\/jats:italic>). In the case with an acute\u2010type ATLL, who carried a der(10)del(10)(p11.2)del(10)(q22q24) translocation, a putative truncated <jats:italic>EPC1<\/jats:italic> gene (<jats:italic>EPC1tr<\/jats:italic>) was identified. Overexpression of EPC1\/ASXL2 enhanced cell growth in T\u2010leukemia cells, and a GAL4\u2010EPC1\/ASXL2 fusion protein showed high transcriptional activity. Although a GAL4\u2010EPC1tr fusion protein did not activate transcription, overexpression of EPC1tr accelerated cell growth in leukemia cells, suggesting that the <jats:italic>EPC1<\/jats:italic> structural abnormalities in the SO4 cell line and in the patient with acute\u2010type ATLL may contribute to leukemogenesis. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20681","type":"journal-article","created":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T18:14:30Z","timestamp":1243620870000},"page":"768-776","source":"Crossref","is-referenced-by-count":23,"title":["Alteration of enhancer of polycomb 1 at 10p11.2 is one of the genetic events leading to development of adult T\u2010cell leukemia\/lymphoma"],"prefix":"10.1002","volume":"48","author":[{"given":"Shingo","family":"Nakahata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Hamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Hidaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Taki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Taniwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Morishita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,5,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412509200"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.5.1884-1896.2004"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2005.10.033"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/268154a0"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-131185"},{"key":"e_1_2_5_7_1","unstructured":"HosodaF KitabayashiI KakazuN FukushimaM AikawaY AbeT HibiS YagiT OhkiM.2002. MOZ Is fused to a novel Polycomb group gene in a therapy\u2010related myelodysplastic syndrome with t(2;8)(p23;p11.2). Submitted (APR\u20102002) to the EMBL\/GenBank\/DDBJ databases (Database: UniProt Entry: Q92794)."},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.101132598"},{"key":"e_1_2_5_9_1","first-page":"845","article-title":"Identification and characterization of ASXL2 gene in silico","volume":"23","author":"Katoh M","year":"2003","journal-title":"Int J Oncol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(200006)28:2<227::AID-GCC12>3.0.CO;2-J"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2485"},{"key":"e_1_2_5_12_1","first-page":"891","article-title":"Rosette\u2010forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus\u2010derived lymphocytes","volume":"49","author":"Minowada J","year":"1972","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/294770a0"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-12-3944"},{"key":"e_1_2_5_15_1","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.4049\/jimmunol.135.6.3995","article-title":"TCGF (IL 2)\u2010receptor induction Factor (S). II. Possible role of ATL\u2010derived factor (ADF) on constitutive IL 2 receptor expression of HTLV\u20101(+) T cell lines","volume":"135","author":"Okada M","year":"1985","journal-title":"J Immunol"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1989.tb02289.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi111"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200995"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02017-07"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-1222"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910190505"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006585200"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.20.4055"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.6161"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199609093442"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.20681","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.20681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:47:32Z","timestamp":1699922852000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.20681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,29]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1002\/gcc.20681"],"URL":"https:\/\/doi.org\/10.1002\/gcc.20681","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,29]]}}}