{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T09:00:29Z","timestamp":1768640429484,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,6,15]],"date-time":"2009-06-15T00:00:00Z","timestamp":1245024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinical characteristics and cytogenetic aberrations were ascertained and reviewed in a population\u2010based consecutive series of 285 pediatric T\u2010cell acute lymphoblastic leukemias (T\u2010ALLs) diagnosed between 1992 and 2006 in the Nordic countries. Informative karyotypic results were obtained in 249 (87%) cases, of which 119 (48%) were cytogenetically abnormal. Most (62%) of the aberrant T\u2010ALLs were pseudodiploid. Structural changes were more common than numerical ones; 86% displayed at least one structural abnormality and 41% at least one numerical anomaly. The most frequent abnormalities were T\u2010cell receptor (TCR) gene rearrangements (20%) [TCR;11p13 (10%), TCR;10q24 (3%), TCR;other (8%)], del(9p) (17%), +8 (14%), del(6q) (12%), and 11q23 rearrangements (6%). The TCR;other group comprised the rare rearrangements t(X;14)(p11;q11), t(X;7)(q22;q34), t(1;14)(p32;q11), ins(14;5)(q11;q?q?), inv(7)(p15q34), t(8;14)(q24;q11), t(7;11)(q34;p15), and t(12;14)(p13;q11). The clinical characteristics of this Nordic patient cohort agreed well with previous larger series, with a median age of 9.0 years, male predominance (male\/female ratio 3.1), median white blood cell (WBC) count of 66.5 \u00d7 10<jats:sup>9<\/jats:sup>\/l, and a high incidence of mediastinal mass and central nervous system involvement (59% and 9.5%, respectively). These features did not differ significantly among the various genetic subgroups. 5\u2010year event\u2010free survival (EFS) and overall survival for all patients were 0.61 (\u00b10.03) and 0.67 (\u00b10.03), respectively. In a multivariate analysis, two factors affected negatively the EFS, namely a WBC count of \u2265200 \u00d7 10<jats:sup>9<\/jats:sup>\/l (<jats:italic>P<\/jats:italic> &lt; 0.001) and the presence of rare TCR rearrangements (<jats:italic>P<\/jats:italic> = 0.001). In conclusion, in this large series of childhood T\u2010ALLs from the Nordic countries, the cytogenetic findings were not associated with risk of therapy failure with the exception of the TCR;other group. However, further prospective and collaborative investigations of this genetically heterogeneous entity are needed to confirm these results. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20684","type":"journal-article","created":{"date-parts":[[2009,6,15]],"date-time":"2009-06-15T19:58:22Z","timestamp":1245095902000},"page":"795-805","source":"Crossref","is-referenced-by-count":35,"title":["Clinical and cytogenetic features of a population\u2010based consecutive series of 285 pediatric T\u2010cell acute lymphoblastic leukemias: Rare T\u2010cell receptor gene rearrangements are associated with poor 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