{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T18:45:58Z","timestamp":1775673958437,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,10,21]],"date-time":"2009-10-21T00:00:00Z","timestamp":1256083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polycomb proteins form multiprotein complexes that repress target genes by chromatin remodeling. In this work, we report that the <jats:italic>SUZ12<\/jats:italic> polycomb gene is over\u2010expressed in bone marrow samples of patients at the blastic phase of chronic myeloid leukemia. We also found a direct interaction between polycomb group genes and the WNT signaling pathway in chronic myeloid leukemia transformation. Electrophoretic mobility shift assay (EMSA), Chromatin immunoprecipitation assay (ChIP), and mass spectrometry assays identified noncanonical WNT pathway members, such as WNT5A and WNT11, bound to the <jats:italic>SUZ12<\/jats:italic> promoter. Immunohistochemistry and immunofluorescence with WNT5A and WNT11 antibodies confirmed nuclear localization. Knockdown of <jats:italic>WNTs 1<\/jats:italic>, <jats:italic>5A<\/jats:italic>, and <jats:italic>11<\/jats:italic> with RNAi approaches showed that WNT members are capable of activating <jats:italic>SUZ12<\/jats:italic> transcription with varying promoter affinities. Finally, we suggest that SUZ12 is blocking cellular differentiation, as <jats:italic>SUZ12<\/jats:italic> knockdown release differentiation programs in chronic myeloid blastic phase (CML\u2010BP) transformed cell line. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20722","type":"journal-article","created":{"date-parts":[[2009,10,21]],"date-time":"2009-10-21T19:00:26Z","timestamp":1256151626000},"page":"107-118","source":"Crossref","is-referenced-by-count":27,"title":["SUZ12 is a candidate target of the non\u2010canonical WNT pathway in the progression of chronic myeloid leukemia"],"prefix":"10.1002","volume":"49","author":[{"given":"Luciana","family":"Pizzatti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Binato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Cofre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadete E.","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Dobbin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Emilia","family":"Haussmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"D'Azambuja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis 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