{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:42:24Z","timestamp":1790502144011,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,4,13]],"date-time":"2010-04-13T00:00:00Z","timestamp":1271116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In a single\u2010nucleotide polymorphism array\u2010based analysis of 56 hepatoblastoma (HB) tumors, allelic imbalances were detected in 37 tumors (66%). Chromosome gains were found in 1q (28 tumors), 2q (24), 6p (8), 8q (8), 17q (6), and 20pq (10), and losses in 1p (6), 4q (9), and 16q (4). Fine mapping delineated the shortest overlapping region (SOR) of gains at 1q32.1 (1.3 Mb) and 2q24.2\u2010q24.3 (4.8 Mb), and losses at 4q34.3\u2010q35.2 (8.7 Mb) and 4q32.3 (1.6 Mb). Uniparental disomy of 11pter\u201011p15.4 (\n                    <jats:italic>IGF2<\/jats:italic>\n                    ) and loss of 11pter\u2010p14.1 were found in 11 and 2 tumors, respectively. Expression of\n                    <jats:italic>HTATIP2<\/jats:italic>\n                    (11p15.1) was absent in 9 of 20 tumors. Amplification was identified in four tumors at 1q32.1, where the candidate oncogene\n                    <jats:italic>MDM4<\/jats:italic>\n                    is located. In the 4q32.3\u2010SRO,\n                    <jats:italic>ANXA10S<\/jats:italic>\n                    , a variant of the candidate tumor suppressor\n                    <jats:italic>ANXA10<\/jats:italic>\n                    , showed no expression in 19 of 24 tumors. Sequence analysis of\n                    <jats:italic>ANXA10S<\/jats:italic>\n                    identified a missense mutation (E36K, c.106G&gt;A) in a HB cell line. Multivariate analysis revealed that both 4q deletion and\n                    <jats:italic>RASSF1A<\/jats:italic>\n                    methylation (relative risks: 4.21 and 7.55, respectively) are independent prognostic factors. Our results indicate that allelic imbalances and gene expression patterns provide possible diagnostic and prognostic markers, as well as therapeutic targets in a subset of HB. \u00a9 2010 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/gcc.20770","type":"journal-article","created":{"date-parts":[[2010,4,13]],"date-time":"2010-04-13T10:52:48Z","timestamp":1271155968000},"page":"596-609","source":"Crossref","is-referenced-by-count":42,"title":["Genome\u2010wide analysis of allelic imbalances reveals 4q deletions as a poor prognostic factor and\n                    <i>MDM4<\/i>\n                    amplification at 1q32.1 in hepatoblastoma"],"prefix":"10.1002","volume":"49","author":[{"given":"Yasuhito","family":"Arai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Haruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuiko","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjiro","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Nakagawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Horie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Yamaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiso","family":"Hiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,4,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.067975"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-7-41"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1712"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10632"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.2799"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890901)64:5<1082::AID-CNCR2820640520>3.0.CO;2-G"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20572"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02471004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604754"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23613"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.929901"},{"key":"e_1_2_6_13_1","first-page":"8763","article-title":"TIP30 deficiency increases susceptibility to tumorigenesis","volume":"63","author":"Ito M","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_6_14_1","volume-title":"Committee on histological classification of childhood tumors. 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