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In addition to the t(14;18), eight unique balanced translocations were found. Commonly reported FL\u2010associated copy number regions were revealed including losses of 1p32\u201036, 6q, and 10q, and gains of 1q, 6p, 7, 12, 18, and X. The most frequent regions affected by copy\u2010neutral loss of heterozygosity were 1p36.33 (28%), 6p21.3 (20%), 12q21.2\u2010q24.33 (16%), and 16p13.3 (24%). We also identified by SNP analysis, 45 aberrant regions that each affected one gene, including <jats:italic>CDKN2A, CDKN2B, FHIT, KIT, PEX14<\/jats:italic>, and <jats:italic>PTPRD<\/jats:italic>, which were associated with canonical pathways involved in tumor development. This study illustrates the power of using complementary high\u2010resolution platforms on paired tumor\/normal specimens and computational analysis to provide potential insights into the significance of single\u2010gene somatic aberrations in FL tumorigenesis. \u00a9 2010 Wiley\u2010Liss,Inc.<\/jats:p>","DOI":"10.1002\/gcc.20780","type":"journal-article","created":{"date-parts":[[2010,4,26]],"date-time":"2010-04-26T15:09:28Z","timestamp":1272294568000},"page":"669-681","source":"Crossref","is-referenced-by-count":44,"title":["High resolution analysis of follicular lymphoma genomes reveals somatic recurrent sites of copy\u2010neutral loss of heterozygosity and copy number alterations that target single genes"],"prefix":"10.1002","volume":"49","author":[{"given":"K\u2010John J.","family":"Cheung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen","family":"Delaney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Ben\u2010Neriah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacquie","family":"Schein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohrab P.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Mungall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adele","family":"Telenius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merrill","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph M.","family":"Connors","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randy D.","family":"Gascoyne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco A.","family":"Marra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas E.","family":"Horsman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,4,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800631"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1999.01347.x"},{"key":"e_1_2_6_4_1","first-page":"285","article-title":"Cytogenetic evaluation of bone marrow involvement in non\u2010Hodgkin's lymphomas. 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