{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:57:20Z","timestamp":1763704640425},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,6,29]],"date-time":"2010-06-29T00:00:00Z","timestamp":1277769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The <jats:italic>ETV6\/ABL1<\/jats:italic> (<jats:italic>TEL\/ABL<\/jats:italic>) fusion gene is a rare aberration in malignant disorders. Only 19 cases of <jats:italic>ETV6\/ABL1<\/jats:italic>\u2010positive hematological malignancy have been published, diagnosed with chronic myeloid leukemia, other types of chronic myeloproliferative neoplasm, acute myeloid leukemia or acute lymphoblastic leukemia (ALL). This study reports three new cases (aged 8 months, 5 years, and 33 years) of ALL with the <jats:italic>ETV6\/ABL1<\/jats:italic> fusion found by screening 392 newly diagnosed ALL patients (335 children and 57 adults). A thorough review of the literature and an analysis of all published data, including the three new cases, suggest poor prognosis of <jats:italic>ETV6\/ABL1<\/jats:italic>\u2010positive acute leukemias. The course of the disease in the two pediatric patients is characterized by minimal residual disease monitoring, using quantification of both the <jats:italic>ETV6\/ABL1<\/jats:italic> transcript and immunoreceptor gene rearrangements. Eosinophilia could not be confirmed as a hallmark of the <jats:italic>ETV6\/ABL1<\/jats:italic>\u2010positive disease. Studies of neonatal blood spots demonstrated that, in the child diagnosed at five years, the <jats:italic>ETV6\/ABL1<\/jats:italic> fusion initiating the ALL originated prenatally. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20796","type":"journal-article","created":{"date-parts":[[2010,6,29]],"date-time":"2010-06-29T20:11:58Z","timestamp":1277842318000},"page":"873-884","source":"Crossref","is-referenced-by-count":33,"title":["Acute leukemias with <i>ETV6\/ABL1<\/i> (<i>TEL\/ABL<\/i>) fusion: Poor prognosis and prenatal origin"],"prefix":"10.1002","volume":"49","author":[{"given":"Jan","family":"Zuna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marketa","family":"Zaliova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Muzikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libuse","family":"Lizcova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzana","family":"Zemanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Brezinova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Votava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Marschalek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Stary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Trka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,6,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199711)20:3<299::AID-GCC11>3.0.CO;2-K"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.6065"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2008.05.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04391.x"},{"key":"e_1_2_7_6_1","first-page":"2003","article-title":"A TEL\/ABL fusion gene on chromosome 12p13 in a case of Ph\u2010, BCR\u2010atypical CML","volume":"10","author":"Brunel V","year":"1996","journal-title":"Leukemia"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-6-100"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.12.4947"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.8.4584"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/363358a0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403135"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.25.13950"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.8.4107"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1164"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_7_16_1","unstructured":"1995 ISCN S. 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