{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:53:39Z","timestamp":1792079619482,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,10,14]],"date-time":"2010-10-14T00:00:00Z","timestamp":1287014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Angiosarcoma (AS) is a distinct group of sarcomas characterized by upregulation of vascular\u2010specific receptor tyrosine kinases, including\n                    <jats:italic>TIE1<\/jats:italic>\n                    ,\n                    <jats:italic>KDR<\/jats:italic>\n                    ,\n                    <jats:italic>TEK<\/jats:italic>\n                    , and\n                    <jats:italic>FLT1.<\/jats:italic>\n                    In keeping with the clinical heterogeneity, gene\u2010expression profiling distinguishes two AS genomic clusters, which correlate with anatomical location and prior exposure to radiation. Furthermore, a high percentage of secondary AS, but not primary AS, shows distinct 8q24 chromosomal gains, due to\n                    <jats:italic>MYC<\/jats:italic>\n                    amplification. In this study, we mined the transcriptional output of 10 secondary and 11 primary AS to better define the dichotomy in the pathogenesis of these two clinical subsets. The oncogenic role of\n                    <jats:italic>MYC<\/jats:italic>\n                    was investigated further in secondary AS as well as in radiation\u2010induced atypical vascular lesions (AVL) and other radiation\u2010associated sarcomas. High\u2010level\n                    <jats:italic>MYC<\/jats:italic>\n                    amplification was found in 100% of secondary AS, but in none of the AVL or other radiation\u2010associated sarcomas. Coamplification of\n                    <jats:italic>FLT4<\/jats:italic>\n                    (encoding VEGFR3) was identified in 25% of secondary AS, but not in other types. Our findings reinforce the distinct pathogenesis of AS subtypes, with\n                    <jats:italic>MYC<\/jats:italic>\n                    amplification being an early, but necessary event in secondary AS. Secondary genetic hits, such as\n                    <jats:italic>FLT4<\/jats:italic>\n                    gene coamplification or\n                    <jats:italic>KDR<\/jats:italic>\n                    mutations, may play a role in tumor progression as well as potential therapeutic targeting. \u00a9 2010 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/gcc.20827","type":"journal-article","created":{"date-parts":[[2010,10,14]],"date-time":"2010-10-14T12:42:28Z","timestamp":1287060148000},"page":"25-33","source":"Crossref","is-referenced-by-count":322,"title":["Consistent\n                    <i>MYC<\/i>\n                    and\n                    <i>FLT4<\/i>\n                    gene amplification in radiation\u2010induced angiosarcoma but not in other radiation\u2010associated atypical vascular lesions"],"prefix":"10.1002","volume":"50","author":[{"given":"Tianhua","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning\u2010En","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Singer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Maki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina R","family":"Antonescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2245"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-2068"},{"key":"e_1_2_6_4_1","first-page":"38","article-title":"Utilization management and data acquisition: A case study","volume":"10","author":"Blackwood MJ","year":"1994","journal-title":"Benefits 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