{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:02:56Z","timestamp":1761919376858},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,10,19]],"date-time":"2010-10-19T00:00:00Z","timestamp":1287446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mature B\u2010cell neoplasms frequently result from translocations involving the <jats:italic>IGH<\/jats:italic> gene localized on 14q32. In rare instances, combinations of different <jats:italic>IGH<\/jats:italic> rearrangements were described, and even coincidence of three genetic lymphoma\u2010specific events has been rarely reported. We here present eight patients with triple hit lymphoma, and two with four different lymphoma specific events detected by chromosome banding analysis and interphase FISH (seven males, three females, 47\u201382 years). All showed bone marrow involvement (Burkitt's lymphoma: <jats:italic>n<\/jats:italic> = 5, diffuse large B\u2010cell lymphoma: <jats:italic>n<\/jats:italic> = 2; features intermediate between BL\/DLBCL: <jats:italic>n<\/jats:italic> = 1; secondary aggressive B\u2010cell lymphoma: <jats:italic>n<\/jats:italic> = 1; follicular lymphoma: <jats:italic>n<\/jats:italic> = 1). Eight patients had triple hit lymphoma combining <jats:italic>IGH\u2010BCL2<\/jats:italic>\/t(14;18)(q32;q21), <jats:italic>MYC<\/jats:italic>\/8q24, and <jats:italic>BCL<\/jats:italic>6\/3q27 rearrangements. Two showed an additional <jats:italic>IGH\u2010CCND1<\/jats:italic>\/t(11;14)(q13;q32) as fourth genetic event (according to research of the Mitelman database, the first reports on four genetic hits in lymphomas). All cases had complex aberrant karyotypes (median, 11 cytogenetic alterations per patient). Interphase FISH revealed a high rate of <jats:italic>CDKN2A<\/jats:italic> deletions (five of nine cases investigated; 56%), being homozygous in two of these cases. At the time of study, four of nine patients with follow\u2010up data were alive (44%), one of these in remission. The two patients with four genetic hits died 6 and 9 days from diagnosis. Additional cases of lymphomas with three or four genetic hits should be collected to evaluate whether their clinical course differs from dual hit lymphomas. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20831","type":"journal-article","created":{"date-parts":[[2010,10,19]],"date-time":"2010-10-19T17:51:22Z","timestamp":1287510682000},"page":"43-50","source":"Crossref","is-referenced-by-count":29,"title":["Several lymphoma\u2010specific genetic events in parallel can be found in mature B\u2010cell neoplasms"],"prefix":"10.1002","volume":"50","author":[{"given":"Ulrike","family":"Bacher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Haferlach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Alpermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Kern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Schnittger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Haferlach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,10,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-006-0188-3"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1999.01347.x"},{"key":"e_1_2_5_4_1","article-title":"Diffuse large B\u2010cell lymphoma with concordant bone marrow involvement has peculiar genomic profile and poor clinical outcome","author":"Chigrinova E","journal-title":"Hematol Oncol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.7058"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2006.07.005"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055759"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-005322"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200107000-00001"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404935"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20013"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-10-247122"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-212191"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20483"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11305"},{"key":"e_1_2_5_16_1","unstructured":"MitelmanF JohanssonB MertensF.2009. Mitelman Database of Chromosome Aberrations in Cancer. Available at:http:\/\/cgap.nci.nih.gov\/Chromosomes\/Mitelman. Last accessed October 2009."},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.344"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05236.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cd3aeb"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401910"},{"key":"e_1_2_5_21_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.005355"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2006.07.016"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.20831","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.20831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T17:29:35Z","timestamp":1700587775000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.20831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,19]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.1002\/gcc.20831"],"URL":"https:\/\/doi.org\/10.1002\/gcc.20831","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,19]]}}}