{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T17:34:44Z","timestamp":1785692084350,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,12,13]],"date-time":"2010-12-13T00:00:00Z","timestamp":1292198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Renal Medullary Carcinoma (RMC) is an aggressive malignancy that affects young black individuals with sickle cell trait. No effective treatment is available, resulting in an ominous clinical course, with overall survival averaging less than four months. We report rearrangement of the ALK receptor tyrosine kinase in a pediatric case of RMC harboring a t(2;10)(p23;q22) translocation. Mass spectrometry\u2010based proteomic evaluation identified a novel ALK oncoprotein in which the cytoskeletal protein vinculin (VCL) was fused to the ALK kinase domain. The resulting VCL\u2010ALK fusion does not contain known self\u2010association domains, but includes the talin binding domains of vinculin. We demonstrate coprecipitation of strongly tyrosine phosphorylated talins with the VCL\u2010ALK oncoprotein, suggesting that ALK oncogenic crossphosphorylation is mediated by interactions between neighboring VCL\u2010ALK proteins on a talin scaffold. This report widens the spectrum of ALK\u2010related tumors and ALK fusion partners, and provides a rationale for treating RMC with targeted ALK inhibitors. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20839","type":"journal-article","created":{"date-parts":[[2010,12,14]],"date-time":"2010-12-14T14:10:15Z","timestamp":1292335815000},"page":"146-153","source":"Crossref","is-referenced-by-count":144,"title":["<i>ALK<\/i> rearrangement in sickle cell trait\u2010associated renal medullary carcinoma"],"prefix":"10.1002","volume":"50","author":[{"given":"Adri\u00e1n","family":"Mari\u00f1o\u2010Enr\u00edquez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Bin","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B.","family":"Weldon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio R.","family":"P\u00e9rez\u2010Atayde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207813"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.12.005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960701)78:1<128::AID-CNCR18>3.0.CO;2-1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02610"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"15S","DOI":"10.1200\/jco.2010.28.18_suppl.3","article-title":"Clinical activity of the oral ALK inhibitor, PF\u201002341066, in ALK\u2010positive patients with non\u2010small cell lung cancer (NSCLC)","volume":"28","author":"Bang Y","year":"2010","journal-title":"J Clin Oncol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.228.10.1279"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.4.2312"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2007.07.012"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007056"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07399"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1249"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00104-6"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199501000-00001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.5.1483"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506514103"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/1044-0305(94)80016-2"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07397"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07398"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880205"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64550-6"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2382"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64946-2"},{"key":"e_1_2_6_24_1","article-title":"Epithelioid inflammatory myofibroblastic sarcoma: an aggressive intra\u2010abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK","author":"Marino\u2010Enriquez A","journal-title":"Am J Surg Pathol"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8122112"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07261"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-2762"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.229"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2590453"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67733-6"},{"key":"e_1_2_6_31_1","article-title":"Activity of IPI\u2010504, a novel heat\u2010shock protein 90 inhibitor, in patients with molecularly defined non\u2010small\u2010cell lung cancer","author":"Sequist LV","journal-title":"J Clin Oncol Epub"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(199702)64:2<295::AID-JCB12>3.0.CO;2-I"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05945"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199912)33:6<551::AID-MPO5>3.0.CO;2-5"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)02154-4"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/01913120802591875"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800934"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2006.07.004"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.20839","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.20839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T11:56:46Z","timestamp":1700567806000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.20839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,13]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1002\/gcc.20839"],"URL":"https:\/\/doi.org\/10.1002\/gcc.20839","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,13]]}}}