{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:39:12Z","timestamp":1791247152514,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T00:00:00Z","timestamp":1294876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In B\u2010cell malignancies, genes implicated in B\u2010cell differentiation, germinal center formation, apoptosis, and cell cycle regulation are juxtaposed to immunoglobulin loci through chromosomal translocations. In this study, we identified the BTB and CNC homology 2 (<jats:italic>BACH2<\/jats:italic>) gene as a novel translocation partner of the immunoglobulin heavy chain (<jats:italic>IGH<\/jats:italic>) locus in a patient with <jats:italic>IGH\u2010MYC<\/jats:italic>\u2010positive, highly aggressive B\u2010cell lymphoma\/leukemia carrying der(14)t(8;14) and del(6)(q15). Fluorescence in situ hybridization analysis using an <jats:italic>IGH\/MYC<\/jats:italic> probe detected an <jats:italic>IGH\u2010MYC<\/jats:italic> fusion signal on der(14) and <jats:italic>IGH<\/jats:italic> signal on del(6). Genome copy number analysis showed a deletion in the 6q15\u201025 region and a centromeric breakpoint within the <jats:italic>BACH2<\/jats:italic> gene. cDNA bubble polymerase chain reaction using <jats:italic>BACH2<\/jats:italic> primers revealed that the first exon of <jats:italic>C<\/jats:italic>\u03b4 was fused to the 5\u2032\u2010untranslated region of <jats:italic>BACH2<\/jats:italic> exon 2. The <jats:italic>C<\/jats:italic>\u03b4\u2013<jats:italic>BACH2<\/jats:italic> fusion transcript consisted of exon 1 of <jats:italic>C<\/jats:italic>\u03b4 and exons 2 to 9 of <jats:italic>BACH2<\/jats:italic>, encompassing the entire <jats:italic>BACH2<\/jats:italic> coding region, and the <jats:italic>BACH2<\/jats:italic> was highly expressed in this patient. These results indicate that <jats:italic>C<\/jats:italic>\u03b4\u2013<jats:italic>BACH2<\/jats:italic> fusion may cause constitutive activation of <jats:italic>BACH2<\/jats:italic>. Although additional screening of 47 samples of B\u2010cell non\u2010Hodgkin's lymphoma (B\u2010NHL) patients and 29 cell lines derived from B\u2010cell malignancies by double\u2010color fluorescence in situ hybridization analysis detected a split signal with deletion of centromeric region of <jats:italic>BACH2<\/jats:italic> only in a patient with follicular lymphoma, <jats:italic>BACH2<\/jats:italic> was highly expressed in lymphoma cells of the patient and B\u2010NHL cell lines with <jats:italic>IGH\u2010MYC<\/jats:italic> translocation. These findings suggest that BACH2 plays a critical role in B\u2010cell lymphomagenesis, especially related to <jats:italic>IGH\u2010MYC<\/jats:italic> translocation in some way. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20845","type":"journal-article","created":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T19:37:33Z","timestamp":1294947453000},"page":"207-216","source":"Crossref","is-referenced-by-count":36,"title":["Identification of <i>IGHC<\/i>\u03b4\u2013<i>BACH2<\/i> fusion transcripts resulting from cryptic chromosomal rearrangements of 14q32 with 6q15 in aggressive B\u2010cell 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