{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:38:56Z","timestamp":1791247136508,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,3,15]],"date-time":"2011-03-15T00:00:00Z","timestamp":1300147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Abnormalities of the long arm of chromosome 6 are a common feature in various B\u2010cell malignancies. In most cases, the genes involved have not yet been clearly identified. We have molecularly characterized the recently established Burkitt lymphoma cell line BLUE\u20101 that carries a t(6;20)(q15;q11.2) rearrangement in addition to the typical t(8;14) with <jats:italic>MYC<\/jats:italic>\u2010<jats:italic>IGH<\/jats:italic> fusion. To identify the gene loci involved on both chromosomes we applied a sequential BAC clone mapping strategy. By using RT\u2010PCR we were finally able to detect a chimeric mRNA transcript showing a fusion of the first (non\u2010coding) exon of <jats:italic>BACH2<\/jats:italic> (BTB and CNC homology 1, basic leucine zipper transcription factor 2) on 6q15 to the second exon of <jats:italic>BCL2L1<\/jats:italic> (<jats:italic>BCL\u2010X<\/jats:italic>) on 20q11. Various fusion transcripts were detected for different <jats:italic>BCL2L1<\/jats:italic> (<jats:italic>BCL\u2010XL<\/jats:italic>) isoforms. The fusion ultimately results in strong expression of the BCL2L1 (BCL\u2010XL) anti\u2010apoptosis protein, as demonstrated by immunoblotting. This is the first report that shows the involvement of both <jats:italic>BCL2L1<\/jats:italic> and the transcription factor <jats:italic>BACH2<\/jats:italic> in a chromosomal rearrangement. It points to <jats:italic>BACH2<\/jats:italic> as a possibly important target in lymphomas with 6q aberrations, although other genes on 6q are probably also involved in these cases. Moreover, it suggests that members of the <jats:italic>BCL2<\/jats:italic> anti\u2010apoptosis gene family other than <jats:italic>BCL2<\/jats:italic> itself might also be involved in lymphoma. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20863","type":"journal-article","created":{"date-parts":[[2011,3,15]],"date-time":"2011-03-15T15:59:22Z","timestamp":1300204762000},"page":"389-396","source":"Crossref","is-referenced-by-count":23,"title":["A <i>BACH2\u2010BCL2L1<\/i> fusion gene resulting from a t(6;20)(q15;q11.2) chromosomal translocation in the lymphoma cell line BLUE\u20101"],"prefix":"10.1002","volume":"50","author":[{"given":"Seval","family":"T\u00fcrkmen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Riehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Klopocki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Molkentin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Reinhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Burmeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.1150"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.11.025"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.281"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90508-N"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003548"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2006.03.026"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199906)25:2<123::AID-GCC8>3.0.CO;2-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc883"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2006.07.005"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.09.007"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-212191"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800500"},{"key":"e_1_2_6_14_1","first-page":"265","volume-title":"WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues","author":"Kluin PM","year":"2008"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.134"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2199-10-2"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404542"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.01.004"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02596"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.257"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607592200"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.11.6083"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.1626"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203716"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cd3aeb"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63184-7"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.005355"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.20863","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.20863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T06:39:42Z","timestamp":1697438382000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.20863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,15]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1002\/gcc.20863"],"URL":"https:\/\/doi.org\/10.1002\/gcc.20863","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,15]]}}}