{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:15:08Z","timestamp":1790147708087,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T00:00:00Z","timestamp":1300752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Approximately 25,000 ovarian cancers are diagnosed in the United States annually, and 75% of cases are in the advanced stage when they are largely incurable. There is a critical need for improved early detection tools and development of novel treatments. Recently, we showed that among 20q13\u2010amplified genes in ovarian cancer, <jats:italic>ADRM1<\/jats:italic> overexpression was the most highly correlated with amplification and was significantly upregulated with respect to stage, recurrence, and metastasis. In addition, overexpression of <jats:italic>ADRM1<\/jats:italic> correlated significantly with shorter time to recurrence and overall survival. Herein, array\u2010CGH and microarray expression of ovarian cancer cell lines provides evidence consistent with the primary tumor data that <jats:italic>ADRM1<\/jats:italic> is a 20q13 amplification target. Knockdown of <jats:italic>ADRM1<\/jats:italic> in amplified ovarian cell\u2010line OAW42 results in downregulation of growth factor <jats:italic>GIPC1<\/jats:italic> and upregulation of tumor\u2010suppressor <jats:italic>RECK<\/jats:italic> RNA and protein. In our dataset of 141 ovarian primary tumors, <jats:italic>ADRM1<\/jats:italic> overexpression significantly correlates with <jats:italic>GIPC1<\/jats:italic> overexpression. In addition, there is a significant anticorrelation between <jats:italic>ADRM1<\/jats:italic> overexpression and <jats:italic>RECK<\/jats:italic> expression. Further research is necessary to determine whether targeting knockdown of <jats:italic>ADRM1<\/jats:italic> in 20q13\u2010amplified ovarian cancers results in growth inhibition and tumor suppression via downstream targets <jats:italic>GIPC1<\/jats:italic> and <jats:italic>RECK<\/jats:italic>. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20868","type":"journal-article","created":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T15:50:21Z","timestamp":1300809021000},"page":"434-441","source":"Crossref","is-referenced-by-count":18,"title":["Knockdown of ovarian cancer amplification target <i>ADRM1<\/i> leads to downregulation of <i>GIPC1<\/i> and upregulation of <i>RECK<\/i>"],"prefix":"10.1002","volume":"50","author":[{"given":"Marlena S.","family":"Fejzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuck","family":"Ginther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Dering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natarajan","family":"Venkatesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gottfried","family":"Konecny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Karlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis J.","family":"Slamon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013654"},{"key":"e_1_2_5_3_1","first-page":"815","article-title":"[Silencing of ADRM1 by RNA interference suppresses proliferation of colorectal cancer cells]","volume":"31","author":"Chen W","year":"2009","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"e_1_2_5_4_1","first-page":"531b","article-title":"Knockdown of the novel proteasome subunit ADRM1 located on the 20q13 amplicon inhibits colorectal cancer cell migration, survival and tumorigenicity","volume":"21","author":"Chen W","year":"2009","journal-title":"Oncol 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