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Nonetheless, they show distinct clinical presentations, suggesting that they may represent two different biological entities. To investigate the genetic characteristics of T\u2010LBL and T\u2010ALL, we used genomic and transcriptional profiling approaches. Genome\u2010wide gene expression profiling, performed on 20 T\u2010LBL and 10 T\u2010ALL diagnostic specimens, revealed that the two malignancies shared a large fraction of their transcriptional profile while a subset of genes appeared to be differentially expressed in T\u2010LBL versus T\u2010ALL. This signature included genes involved in chemotactic responses and angiogenesis, which may play a role in tumor cell localization. Genome\u2010wide copy number alteration analysis was performed on a subset of the samples analyzed by gene expression profiling and detected 41 recurrently altered genetic loci. Although most aberrations were found in both entities, several were selectively identified in T\u2010LBL or T\u2010ALL. In addition, <jats:italic>NOTCH1<\/jats:italic> mutational status was found to correlate with a subset of genetic aberrations. Taken together, these results suggest that T\u2010LBL and T\u2010ALL are indeed two distinct diseases with unique transcriptional and genetic characteristics. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20924","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T05:47:11Z","timestamp":1314856031000},"page":"1063-1075","source":"Crossref","is-referenced-by-count":59,"title":["T\u2010cell lymphoblastic lymphoma shows differences and similarities with T\u2010cell acute lymphoblastic leukemia by genomic and gene expression 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