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Unfortunately, identification of TK fusions has been hampered by experimental limitations. Here, we developed version 2.0 of a genomically based systematic kinase fusion screen and used it to detect a novel imatinib\u2010sensitive <jats:italic>C6orf204\u2010PDGFRB<\/jats:italic> fusion in a patient with precursor T lymphoblastic lymphoma (T\u2010ALL) and an associated myeloproliferative neoplasm with eosinophilia. These data validate the ability of this targeted capture\u2010sequencing approach to detect TK fusion events in small amounts of DNA extracted directly from patient samples. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20930","type":"journal-article","created":{"date-parts":[[2011,9,21]],"date-time":"2011-09-21T17:19:46Z","timestamp":1316625586000},"page":"54-65","source":"Crossref","is-referenced-by-count":22,"title":["Systematic screen for tyrosine kinase rearrangements identifies a novel <i>C6orf204\u2010PDGFRB<\/i> fusion in a patient with recurrent T\u2010ALL and an associated myeloproliferative 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