{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:54:48Z","timestamp":1788893688332,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T00:00:00Z","timestamp":1319760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neoplasms morphologically similar to mixed tumors and myoepitheliomas of the salivary glands, under the broad concept of myoepithelial neoplasia, have recently been defined in the skin and soft tissue; however, to date, no data have supported a shared genetic background with their salivary gland counterpart. From a large body of research, it has been well established that rearrangement of <jats:italic>pleomorphic adenoma gene 1<\/jats:italic> (<jats:italic>PLAG1<\/jats:italic>) leads to aberrant expression of its protein and is pathogenically relevant in the development of salivary mixed tumors. On the other hand, in soft tissue lesions, compelling evidence suggests that <jats:italic>EWSR1<\/jats:italic> is involved in a significant subset. To examine the hypothesis that there is a genetic link between these histologically similar tumors at different sites, we randomly selected 20 benign myoepitheliomas\/mixed tumors of skin and soft tissue (10 cases each). Nineteen cases could be immunostained for PLAG1, of which 11 cases showed distinct nuclear staining with moderate or strong intensity in a significant number of cells. Interphase fluorescence in situ hybridization for <jats:italic>PLAG1<\/jats:italic> was successfully performed in 11 cases (seven in skin and four in soft tissue) and was positive for gene rearrangement in eight cases (five in skin and three in soft tissue). All <jats:italic>PLAG1<\/jats:italic>\u2010rearranged tumors, except one, had clear\u2010cut ductal structures and were immunoreactive for PLAG1. In our series, tumors with <jats:italic>PLAG1<\/jats:italic> alteration shared a common morphologic phenotype characterized by prominent tubuloductal differentiation, suggesting that myoepithelial neoplasms with genuine salivary gland\u2010like morphology, so\u2010called soft tissue\/cutaneous mixed tumors, are genetically related to their salivary gland counterpart. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.20938","type":"journal-article","created":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T13:28:59Z","timestamp":1319808539000},"page":"140-148","source":"Crossref","is-referenced-by-count":117,"title":["A subset of cutaneous and soft tissue mixed tumors are genetically linked to their salivary gland counterpart"],"prefix":"10.1002","volume":"51","author":[{"given":"Armita","family":"Bahrami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Dalton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey F.","family":"Krane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D. M.","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20819"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20346"},{"key":"e_1_2_6_4_1","first-page":"918","article-title":"Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: Identification of SII as a new fusion partner gene","volume":"59","author":"Astrom AK","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_6_5_1","first-page":"1107","article-title":"Evidence of involvement of the PLAG1 gene in lipoblastomas","volume":"16","author":"Astrom A","year":"2000","journal-title":"Int J Oncol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(80)90053-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20168"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20559"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20706"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(93)90054-P"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(82)80140-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780342"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2909"},{"key":"e_1_2_6_14_1","first-page":"13","article-title":"Expression of reciprocal hybrid transcripts of HMGIC and FHIT in a pleomorphic adenoma of the parotid gland","volume":"57","author":"Geurts JM","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31805f6775"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.124"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-169x.2004.00762.x"},{"key":"e_1_2_6_18_1","first-page":"4869","article-title":"PLAG1 fusion oncogenes in lipoblastoma","volume":"60","author":"Hibbard MK","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200309000-00001"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2003.08.016"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197105)27:5<1255::AID-CNCR2820270533>3.0.CO;2-1"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0297-170"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.36.23026"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199701000-00002"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3630"},{"key":"e_1_2_6_26_1","first-page":"299","article-title":"Cytogenetical observations in 100 human benign pleomorphic adenomas: specificity of the chromosomal aberrations and their relationship to sites of localized oncogenes","volume":"6","author":"Mark J","year":"1986","journal-title":"Anticancer Res"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90033-7"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2327"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90042-9"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2005.01.002"},{"key":"e_1_2_6_31_1","first-page":"765","article-title":"PLAG1, the prototype of the PLAG gene family: Versatility in tumour development (review)","volume":"30","author":"Van DF","year":"2007","journal-title":"Int J Oncol"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201660"},{"key":"e_1_2_6_33_1","first-page":"106","article-title":"PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF\u2010II","volume":"60","author":"Voz ML","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/08959374000140011301"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207013"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10307"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.20938","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.20938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T16:42:07Z","timestamp":1697474527000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.20938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,28]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1002\/gcc.20938"],"URL":"https:\/\/doi.org\/10.1002\/gcc.20938","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,28]]}}}