{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:25:05Z","timestamp":1790803505357,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T00:00:00Z","timestamp":1323302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>E<jats:italic>TV6<\/jats:italic> (<jats:italic>TEL<\/jats:italic>) rearrangements are favorable in pediatric acute lymphoblastic leukemia but are less well characterized in myeloid malignancies. We investigated 9,550 patients with myeloid disorders for <jats:italic>ETV6<\/jats:italic> rearrangements by chromosome banding analysis and interphase fluorescence in situ hybridization. <jats:italic>ETV6<\/jats:italic> rearrangements were identified in 51 of 9,550 (0.5%) patients (range, 19.2\u201385.3 years). Frequencies were in detail: acute myeloid leukemia (AML): 40 of 3,798, 1.1%; myelodysplastic syndromes (MDS): 6 of 3,375, 0.2%; myeloproliferative neoplasms (MPNs): 5 of 1,720, 0.3%; MDS\/MPN: 0 of 210; and chronic myelomonocytic leukemia: 0 of 447. Thirty\u2010three different partner bands of <jats:italic>ETV6<\/jats:italic> were identified, and most were recurrent: 3q26 (<jats:italic>n<\/jats:italic> = 10), 5q33 (<jats:italic>n<\/jats:italic> = 4), 17q11 (<jats:italic>n<\/jats:italic> = 3), 22q12 (<jats:italic>n<\/jats:italic> = 3), 5q31 (<jats:italic>n<\/jats:italic> = 2), and 2q31 (<jats:italic>n<\/jats:italic> = 2). Additional chromosomal abnormalities were identified in 29 of 51 (57%) <jats:italic>ETV6<\/jats:italic> rearranged cases. In AML, <jats:italic>ETV6<\/jats:italic> rearrangements were frequently associated with <jats:italic>NPM1<\/jats:italic> (9\/39, 23%) and <jats:italic>RUNX1<\/jats:italic> mutations (6\/31, 19%). The FAB M0 subtype was more frequent in <jats:italic>ETV6<\/jats:italic> rearranged de novo AML than other AML (<jats:italic>P<\/jats:italic> &lt; 0.001); expression of CD7 and CD34 by immunophenotyping was higher in <jats:italic>ETV6<\/jats:italic> rearranged AML compared with other subgroups. Survival of 29 <jats:italic>ETV6<\/jats:italic> rearranged de novo AML was compared with 818 AML from other cytogenetic subgroups. Median overall and event\u2010free survival of <jats:italic>ETV6<\/jats:italic> rearranged cases was similar to the intermediate\u2010risk cohort (26.3 vs. 62.2 months and 14.0 vs. 15.4 months) defined according to Medical Research Council criteria. Our study confirms the variety of <jats:italic>ETV6<\/jats:italic> rearrangements in AML, MDS, and MPNs often in association with other genetic events. Prognosis of <jats:italic>ETV6<\/jats:italic> rearranged de novo AML seems to be intermediate, which should be independently confirmed. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.21918","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T20:58:22Z","timestamp":1323377902000},"page":"328-337","source":"Crossref","is-referenced-by-count":51,"title":["<i>ETV6<\/i> rearrangements are recurrent in myeloid malignancies and are frequently associated with other genetic events"],"prefix":"10.1002","volume":"51","author":[{"given":"Claudia","family":"Haferlach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Bacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Schnittger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Alpermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Zenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Kern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Haferlach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.27656"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-05-091215"},{"key":"e_1_2_6_4_1","first-page":"67","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Bain B","year":"2008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208588"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-4-620"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.4245"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.3.1025"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1182\/blood.V94.5.1820","article-title":"Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11\u2010q12;p13)","volume":"94","author":"Cools J","year":"1999","journal-title":"Blood"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.5.1776"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2007.03.004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.016345"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90322-0"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-254441"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199709042495"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.8997"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti146"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","unstructured":"HuretJL.2011. 12p13 rearrangements in treatment related leukemia. Atlas Genet Cytogenet Oncol Haematol. Available at:http:\/\/atlasgeneticsoncology.org\/Anomalies\/12p13TreatRelLeukID1301.html.","DOI":"10.4267\/2042\/38044"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2010.06.007"},{"key":"e_1_2_6_20_1","volume-title":"Atlas of Clinical Hematology","author":"L\u00f6ffler H","year":"2004"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401070"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.1127"},{"key":"e_1_2_6_23_1","first-page":"564","article-title":"Fusion of ETV6 to MDS\/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders","volume":"57","author":"Peeters P","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.2.682.bloodjournal882682"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.3552"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.1.59"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2248"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-213389"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-255976"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402329"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402121"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10248"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10980"},{"key":"e_1_2_6_34_1","first-page":"881","article-title":"Risk assessment by monitoring expression levels of partial tandem duplications in the MLL gene in acute myeloid leukemia during therapy","volume":"90","author":"Weisser M","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20796"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.21918","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.21918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T04:43:13Z","timestamp":1697517793000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.21918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,8]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1002\/gcc.21918"],"URL":"https:\/\/doi.org\/10.1002\/gcc.21918","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,8]]}}}