{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:05:09Z","timestamp":1761919509255},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T00:00:00Z","timestamp":1324512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Translocations involving immunoglobulin (<jats:italic>IG<\/jats:italic>) loci are the hallmarks of several subtypes of B\u2010cell lymphoma. Common to these translocations is that cellular proto\u2010oncogenes come under the influence of <jats:italic>IG<\/jats:italic> regulatory elements leading to deregulated expression. In case of a breakpoint in the <jats:italic>IGH<\/jats:italic> switch region, oncogene activation can take place on both derivative chromosomes, which means that in principle one translocation can result in concurrent activation of two genes. By fluorescence in situ hybridization (FISH), we identified a case of leukemic B\u2010cell lymphoma in a child with an <jats:italic>IGH<\/jats:italic> break and unknown partner. Subsequent long\u2010distance inverse PCR revealed fusion of <jats:italic>IGH<\/jats:italic> S\u03bc in 14q32 and the 5\u2032 region of <jats:italic>CBFA2T3<\/jats:italic> in 16q24.3, suggesting presence of the t(14;16)(q32;q24.3). Candidate oncogenes targeted through this translocation are <jats:italic>CBFA2T3<\/jats:italic> and <jats:italic>ACSF3<\/jats:italic>, which could be activated on der(16) and der(14), respectively. FISH screening of a population\u2010based cohort of B\u2010cell lymphomas from a prospective trial for the treatment of lymphoma in childhood (BFM\u2010NHL) identified additionally a follicular lymphoma Grade 3\/diffuse large B\u2010cell lymphoma with <jats:italic>IGH\u2010CBFA2T3\/ACSF3<\/jats:italic> juxtaposition. Both lymphomas shared expression of CD10 and CD20 in the absence of TdT, suggesting a germinal center (GC) B\u2010cell origin. Our data indicate that the <jats:italic>CBFA2T3\/ACSF3<\/jats:italic> locus is a novel recurrent oncogenic target of <jats:italic>IGH<\/jats:italic> translocations, which might contribute to the pathogenesis of pediatric GC\u2010derived B\u2010cell lymphoma. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.21919","type":"journal-article","created":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T11:28:44Z","timestamp":1324553324000},"page":"338-343","source":"Crossref","is-referenced-by-count":17,"title":["The <i>CBFA2T3\/ACSF3<\/i> locus is recurrently involved in <i>IGH<\/i> chromosomal translocation t(14;16)(q32;q24) in pediatric B\u2010cell lymphoma with germinal center phenotype"],"prefix":"10.1002","volume":"51","author":[{"given":"Itziar","family":"Salaverria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Akasaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Gesk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Szczepanowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Burkhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lana","family":"Harder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Damm\u2010Welk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilske","family":"Oschlies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfram","family":"Klapper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J. 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