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To gain further insights into the genetic background of NMZL, seven cases were investigated by microarray analysis, G\u2010banding, and FISH. Chromosomal imbalances were observed in 3\/7 cases (43%) with gains of chromosome arms 1q, 8q, and 12q being the most frequent findings. Furthermore, we identified a translocation t(11;14)(q23;q32) involving <jats:italic>IGH<\/jats:italic> and <jats:italic>DDX6<\/jats:italic>. Chromosomal walking, expression analysis, siRNA\u2010mediated gene knockdown and a yeast two hybrid screen were performed for further characterization of the translocation in vitro. In siRNA experiments, <jats:italic>DDX6<\/jats:italic> appeared not to be involved in NF\u2010\u03baB activation as frequently observed for genes promoting lymphomagenesis but was found to interfere with the expression of <jats:italic>BCL6<\/jats:italic> and <jats:italic>BCL2<\/jats:italic> in an NF\u2010\u03baB independent manner. In conclusion, we identified several unbalanced aberrations and a t(11;14) involving <jats:italic>IGH<\/jats:italic> and <jats:italic>DDX6<\/jats:italic> providing evidence for a contribution of <jats:italic>DDX6<\/jats:italic> to lymphomagenesis by deregulation of <jats:italic>BCL6<\/jats:italic> in NMZL. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.22004","type":"journal-article","created":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T09:23:10Z","timestamp":1347355390000},"page":"33-43","source":"Crossref","is-referenced-by-count":13,"title":["t(11;14)(q23;q32) involving <i>IGH<\/i> and <i>DDX6<\/i> in nodal marginal zone 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