{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:33:55Z","timestamp":1790393635598,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T00:00:00Z","timestamp":1350432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Translocations affecting chromosome subband 6p25.3 containing the <jats:italic>IRF4<\/jats:italic> gene have been recently described as characteristic alterations in a molecularly distinct subset of germinal center B\u2010cell\u2010derived lymphomas. Secondary changes have yet only been described in few of these lymphomas. Here, we performed array\u2010comparative genomic hybridization and molecular inversion probe microarray analyses on DNA from 12 formalin\u2010fixed paraffin\u2010embedded and two fresh\u2010frozen <jats:italic>IRF4<\/jats:italic> translocation\u2010positive lymphomas, which together with the previously published data on nine cases allowed the extension of copy number analyses to a total of 23 of these lymphomas. All except one case carried chromosomal imbalances, most frequently gains in Xq28, 11q22.3\u2010qter, and 7q32.1\u2010qter and losses in 6q13\u201016.1, 15q14\u201022.31, and 17p. No recurrent copy\u2010neutral losses of heterozygosity were observed. <jats:italic>TP53<\/jats:italic> point mutations were detected in three of six cases with loss of 17p. Overall this study unravels a recurrent pattern of secondary genetic alterations in <jats:italic>IRF4<\/jats:italic> translocation\u2010positive lymphomas. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.22014","type":"journal-article","created":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T09:50:58Z","timestamp":1350467458000},"page":"150-155","source":"Crossref","is-referenced-by-count":32,"title":["High resolution copy number analysis of <i>IRF4<\/i> translocation\u2010positive diffuse large B\u2010cell and follicular 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