{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:54:37Z","timestamp":1782284077600,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,8]],"date-time":"2012-12-08T00:00:00Z","timestamp":1354924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genetic variations in tumor necrosis factor (<jats:italic>TNF<\/jats:italic>) and interleukin\u2010<jats:italic>10<\/jats:italic> (<jats:italic>IL\u201010<\/jats:italic>) were reported to influence susceptibility to and outcome of patients with non\u2010Hodgkin lymphoma. Therefore, we investigated whether single nucleotide polymorphisms in <jats:italic>TNF<\/jats:italic> and <jats:italic>IL\u201010<\/jats:italic> may play a role in the clinical course of patients with chronic lymphocytic leukemia (CLL). <jats:italic>TNF<\/jats:italic>\u2010308G&gt;A, <jats:italic>IL\u201010<\/jats:italic>\u20103575T&gt;A, and <jats:italic>IL\u201010<\/jats:italic>\u20101082A&gt;G seem to be functionally relevant, were genotyped in 292 previously untreated patients with CLL. The control group consisted of 192 randomly selected blood donors. The patients carrying <jats:italic>TNF<\/jats:italic>\u2010308GG and <jats:italic>IL\u201010<\/jats:italic>\u20101082AA genotypes presented a higher 3\u2010year treatment\u2010free survival (56.6 vs. 40.6%, <jats:italic>P<\/jats:italic> = 0.05) as well as a 10\u2010year overall survival (OS) rates (92.3 vs. 57.6%, <jats:italic>P<\/jats:italic> = 0.005) than those with other <jats:italic>TNF<\/jats:italic>\u2010308 and <jats:italic>IL\u201010<\/jats:italic>\u20101082 genotype combinations. Multivariate analysis demonstrated the Rai stage (<jats:italic>P<\/jats:italic> = 0.0002), <jats:italic>IGHV<\/jats:italic> mutation status (<jats:italic>P<\/jats:italic> = 0.01), <jats:italic>TNF<\/jats:italic>\u2010308G&gt;A (<jats:italic>P<\/jats:italic> = 0.03), and <jats:italic>TNF\/IL\u201010<\/jats:italic> polymorphism\u2010based risk groups (<jats:italic>P<\/jats:italic> = 0.05) to be independent factors predicting OS. When the mutated <jats:italic>IGHV<\/jats:italic> patients were analyzed, the homozygotes <jats:italic>TNF<\/jats:italic>\u2010308GG and <jats:italic>IL\u201010<\/jats:italic>\u20101082AA presented a higher 10\u2010year OS rate than those carrying other <jats:italic>TNF<\/jats:italic>\u2010308 and <jats:italic>IL\u201010<\/jats:italic>\u20101082 genotypes (100 vs. 67.7%, <jats:italic>P<\/jats:italic> = 0.01). In the unmutated <jats:italic>IGHV<\/jats:italic> patients, only the <jats:italic>TNF<\/jats:italic>\u2010308G&gt;A polymorphism influenced OS. The genetic variations in <jats:italic>TNF<\/jats:italic> and <jats:italic>IL\u201010<\/jats:italic> genes work as independent predictors of survival and may play a role in the clinical course of CLL. It suggests inherited ability of the host to shift the balance between the Th1 and Th2 response, which in turn might contribute to the pathogenesis and prognosis of B\u2010cell malignancies. \u00a9 2012 Wiley Periodicals,Inc.<\/jats:p>","DOI":"10.1002\/gcc.22028","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T19:11:53Z","timestamp":1355253113000},"page":"287-296","source":"Crossref","is-referenced-by-count":25,"title":["Polymorphisms of <i>TNF<\/i> and <i>IL\u201010<\/i> genes and clinical outcome of patients with chronic lymphocytic leukemia"],"prefix":"10.1002","volume":"52","author":[{"given":"Ewa","family":"Lech\u2010Maranda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Mlynarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Grzybowska\u2010Izydorczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Borowiec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Pastorczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Cebula\u2010Obrzut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Klimkiewicz\u2010Wojciechowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Wcislo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslaw","family":"Majewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Kotkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadeusz","family":"Robak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Warzocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1184"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.2.812"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4814"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.7.2169.2169"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2005.00553.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2007.00984.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2007.06.007"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.12.4990.bloodjournal87124990"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403244"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.9912636.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.4.915"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btg276"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11350"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.843"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.1.256"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.4.1215.h81602001215_1215_1219"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003050"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.6.3915"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-111658"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200212000-00004"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190500158789"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0654"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02849990"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364364"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4160"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-1850"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-010-0066-1"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-012-0197-7"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009059274"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2003.11.001"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(02)00266-7"},{"key":"e_1_2_5_33_1","first-page":"485","article-title":"The effects of IL\u20102, IL\u20106 and IL\u201010 levels on prognosis in patients with aggressive Non\u2010Hodgkin's Lymphoma (NHL)","volume":"23","author":"Ozdemir F","year":"2004","journal-title":"J Exp Clin Cancer Res"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(03)00022-4"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgl200"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V46.2.219.219"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2010.09.006"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70434-4"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000055216.19866.9A"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2370.1997.tb00001.x"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0324"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4752"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.2.499"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.10.3574"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01176.x"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.2.557"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.7.3195"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.22028","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.22028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T11:35:07Z","timestamp":1698665707000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.22028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,8]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1002\/gcc.22028"],"URL":"https:\/\/doi.org\/10.1002\/gcc.22028","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,8]]}}}