{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T01:33:59Z","timestamp":1755999239434},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,12,8]],"date-time":"2012-12-08T00:00:00Z","timestamp":1354924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chromosome banding analyses reveal secondary chromosome abnormalities in addition to the <jats:italic>MYC<\/jats:italic> translocations t(8;14)(q24;q32), t(8;22)(q24;q11), and t(2;8)(p11;q24) in 60%\u201380% of Burkitt lymphomas\/leukemias (BL). The high incidence of such aberrations indicates that additional changes are important, perhaps necessary, for malignant transformation, i.e., the 8q24\/<jats:italic>MYC<\/jats:italic> rearrangements may not be sufficient. To investigate this possibility, we performed single nucleotide polymorphism (SNP) array analysis on 20 cases of 8q24\/<jats:italic>MYC<\/jats:italic>\u2010positive BL. Nineteen (95%) harbored genomic imbalances; the only case without such aberrations displayed secondary changes by chromosome banding analysis. Thus, all BL cases had abnormalities in addition to the 8q24 translocation. The adult cases harbored more changes (median 3; range 1\u201321) than did the childhood cases (median 1.5; range 0\u20135) (<jats:italic>P<\/jats:italic> = 0.034). Several recurrent aberrations were detected by SNP array analysis, in particular losses of 6q14.1\u2010q22.33, 9p21.3, and 13q14.2\u2010q14.3, gains of 1q23.3\u2010q31.3, chromosome 7, 13q31.3, and partial uniparental isodisomies for 6p12.2\u2010pter, 9p23\u2010pter, and 17p11.2\u2010pter. The molecular genetic consequences of these changes include deletions of the <jats:italic>CDKN2A<\/jats:italic> and <jats:italic>TP53<\/jats:italic> genes, and gains\/losses of several genes, such as <jats:italic>MIR17HG<\/jats:italic> and <jats:italic>E2F2K<\/jats:italic>, involved in the <jats:italic>MYC<\/jats:italic> pathway. Thus, deregulation of the <jats:italic>MYC<\/jats:italic> pathway, both directly through the 8q24\/<jats:italic>MYC<\/jats:italic> translocation and indirectly through secondary genomic imbalances, may be essential not only for the initiation but also for the progression of BL. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.22034","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T19:54:26Z","timestamp":1355255666000},"page":"370-377","source":"Crossref","is-referenced-by-count":7,"title":["Submicroscopic genomic imbalances in burkitt lymphomas\/leukemias: Association with age and further evidence that 8q24\/<i>MYC<\/i> translocations are not sufficient for leukemogenesis"],"prefix":"10.1002","volume":"52","author":[{"given":"Catarina","family":"Lundin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Hjorth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Behrendtz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Ehinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Biloglav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertil","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/318533a0"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00289460"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870010202"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.09.004"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.281"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199702)18:2<84::AID-GCC2>3.0.CO;2-X"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20780"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.02974.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7824"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055759"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm173"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/11.4.1133"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.18.5611"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.12.5413"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403080"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055351"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1416"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870080402"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910320606"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-05-088310"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2009.s.017"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-136465"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900090202"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404691"},{"key":"e_1_2_5_27_1","first-page":"262","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Leoncini L","year":"2008"},{"key":"e_1_2_5_28_1","article-title":"SNP\u2010based mapping arrays reveal high genomic complexity in monoclonal gammopathies, from MGUS to myeloma status","author":"L\u00f3pez\u2010Corral L","journal-title":"Leukemia"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20944"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.09013.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V63.5.1102.1102"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.16.4957"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910240106"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910230107"},{"key":"e_1_2_5_35_1","unstructured":"MitelmanF JohanssonB MertensF. 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