{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:41:42Z","timestamp":1790628102983,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>Over 90<jats:bold>%<\/jats:bold> of infants (&lt;1\u2010year\u2010old) diagnosed with leukemia have pro\u2010B acute lymphoblastic leukemia (ALL) containing the <jats:italic>MLL\u2010AF4<\/jats:italic> fusion. When compared with other forms of paediatric ALL affecting later B\u2010cell differentiation, <jats:italic>MLL\u2010AF4<\/jats:italic> pro\u2010B is associated with a dismal prognosis with a typical 5\u2010year disease\u2010free survival of &lt;20%. MLL\u2010AF4 may be sufficient on its own for leukemogenesis or the gene\u2010fusion product may alternatively predispose transformed cells to global genetic instability, enhancing the acquisition of additional key mutations. To gain insight into the genomic landscape of infant <jats:italic>MLL\u2010AF4<\/jats:italic> pro\u2010B ALL we performed whole genome sequencing of diagnostic leukemic blasts and matched germline samples from three MLL\u2010AF4 pro\u2010B ALL infants. Our analysis revealed few somatic changes (copy number abnormalities, loss of heterozygosity, or single nucleotide variants), demonstrating that only a very small number of mutations are necessary to generate infant MLL\u2010leukemia. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.22090","type":"journal-article","created":{"date-parts":[[2013,7,27]],"date-time":"2013-07-27T00:34:29Z","timestamp":1374885269000},"page":"954-960","source":"Crossref","is-referenced-by-count":54,"title":["The silent mutational landscape of infant <i>MLL\u2010AF4<\/i> pro\u2010B acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"52","author":[{"given":"Sara E.","family":"Dobbins","sequence":"first","affiliation":[{"name":"Molecular and Population Genetics Division of Genetics and Epidemiology Institute of Cancer Research Sutton Surrey SM2 5NG UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy 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