{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:08:29Z","timestamp":1780628909535,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T00:00:00Z","timestamp":1376006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>PCDH10 is epigenetically inactivated in multiple tumor types; however, studies in mature lymphoid malignancies are limited. Here, we have investigated the presence of promoter hypermethylation of the PCDH10 gene in a large cohort of well\u2010characterized subsets of lymphomas. PCDH10 promoter hypermethylation was identified by methylation\u2010specific PCR in 57 to 100% of both primary B\u2010 and T\u2010cell lymphoma specimens and cell lines. These findings were further validated by Sequenom Mass\u2010array analysis. Promoter hypermethylation was also identified in 28.6% cases of reactive follicular hyperplasia, more commonly occurring in states of immune deregulation and associated with rare presence of clonal karyotypic aberrations, suggesting that PCDH10 methylation occurs early in lymphomagenesis. PCDH10 expression was down regulated via promoter hypermethylation in T\u2010 and B\u2010cell lymphoma cell lines. The transcriptional down\u2010regulation resulting from PCDH10 methylation could be restored by pharmacologic inhibition of DNA methyltransferases in cell lines. Both T\u2010 and B\u2010cell lymphoma cell lines harboring methylation\u2010mediated inactivation of PCDH10 were resistant to doxorubicin treatment, suggesting that hypermethylation of this gene might contribute to chemotherapy response. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.22098","type":"journal-article","created":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T06:48:52Z","timestamp":1376030932000},"page":"1030-1041","source":"Crossref","is-referenced-by-count":19,"title":["<i>PCDH10<\/i> promoter hypermethylation is frequent in most histologic subtypes of mature lymphoid malignancies and occurs early in lymphomagenesis"],"prefix":"10.1002","volume":"52","author":[{"given":"Gopeshwar","family":"Narayan","sequence":"first","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center New York Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxu","family":"Xie","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Irving Cancer Research Center, Columbia University Medical Center  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen J.","family":"Freddy","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center New York Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganchimeg","family":"Ishdorj","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Irving Cancer Research Center, Columbia University Medical Center  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Do","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Irving Cancer Research Center, Columbia University Medical Center  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash","family":"Satwani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Columbia University Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hema","family":"Liyanage","sequence":"additional","affiliation":[{"name":"Applications and Technology Division Sequenom Inc. San Diego CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center New York Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Kisselev","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center New York Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhadra V.","family":"Nandula","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center New York Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Scotto","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bachir","family":"Alobeid","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center New York Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Savage","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Tycko","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center New York Presbyterian Hospital New York NY"},{"name":"Institute for Cancer Genetics, Irving Cancer Research Center, Columbia University Medical Center  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen A.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University Medical Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govind","family":"Bhagat","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center New York Presbyterian Hospital New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vundavalli V.","family":"Murty","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Medical Center New York Presbyterian Hospital New York NY"},{"name":"Institute for Cancer Genetics, Irving Cancer Research Center, Columbia University Medical Center  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3130"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605505"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.8.2666.008k02_2666_2671"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2008.09.008"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4437"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.343"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204640"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"704","DOI":"10.3892\/ijmm.2012.880","article-title":"Protocadherin\u201010 is involved in angiogenesis and methylation correlated with multiple myeloma","volume":"29","author":"Li Y","year":"2012","journal-title":"Int J Mol Med"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20703"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20922"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-198911"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(92)90349-D"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3402"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-075027"},{"key":"e_1_2_5_16_1","first-page":"180","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH CE","year":"2008"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3410"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2006.08.014"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.04490"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-169X.2008.00991.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209154"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06512.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.10.050"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.101"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-010-9591-3"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.22098","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.22098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T04:12:27Z","timestamp":1696565547000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.22098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,9]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1002\/gcc.22098"],"URL":"https:\/\/doi.org\/10.1002\/gcc.22098","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,9]]}}}