{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T01:22:52Z","timestamp":1778116972512,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>Stress\u2010induced phosphoprotein1 (STIP1) is a candidate biomarker in epithelial ovarian cancer (EOC). In this study, we investigated in detail the expression of STIP1, as well as its functions, in EOC. STIP1 expression was assessed by immunohistochemistry (IHC) and the results were compared with clinicopathologic factors, including survival data. The effects of <jats:italic>STIP1<\/jats:italic> gene silencing via small interfering RNA (siRNA) were examined in EOC cells and a xenograft model. The expression of STIP1 protein in EOC was significantly higher than in the other study groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and this increase of expression was significantly associated with tumor stage (<jats:italic>P<\/jats:italic>\u2009=\u20090.005), tumor grade (<jats:italic>P<\/jats:italic>\u2009=\u20090.029), and lymph node metastasis (<jats:italic>P<\/jats:italic>\u2009=\u20090.020). In multivariate analysis, overall survival in EOC was significantly shorter in cases with high STIP1 expression (HR\u2009=\u20092.78 [1.01\u20137.63], <jats:italic>P<\/jats:italic>\u2009=\u20090.047). <jats:italic>STIP1<\/jats:italic> silencing in EOC cells resulted in inhibition of cell proliferation and invasion. In addition, in vivo experiments using <jats:italic>STIP1<\/jats:italic> siRNA clearly showed a strong inhibition of tumor growth and a modulation of expression of prosurvival and apoptotic genes, further suggesting that <jats:italic>STIP1<\/jats:italic> silencing can prevent cell proliferation and invasion. In conclusion, increased STIP1 expression is associated with poor survival outcome in EOC, and STIP1 may represent a useful therapeutic target in EOC patients. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.22136","type":"journal-article","created":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T07:32:55Z","timestamp":1391239975000},"page":"277-288","source":"Crossref","is-referenced-by-count":30,"title":["Expression of stress\u2010induced phosphoprotein1 (STIP1) is associated with tumor progression and poor prognosis in epithelial ovarian cancer"],"prefix":"10.1002","volume":"53","author":[{"given":"Hanbyoul","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Gangnam Severance Hospital Yonsei University College of Medicine Seoul Korea"},{"name":"Institute of Women's Life Medical Science Yonsei University College of Medicine Seoul 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Pathology, Center for Cancer Research National Cancer Institute, National Institutes of Health Bethesda MD"},{"name":"Department of Thoracic Surgery Shiga University of Medical Science Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae","family":"Hyon Park","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Gangnam Severance Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucienne","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Gangnam Severance Hospital Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon\u2010Yong","family":"Chung","sequence":"additional","affiliation":[{"name":"Tissue Array Research Program and Applied Molecular Pathology Lab., Laboratory of Pathology, Center for Cancer Research National Cancer 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