{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:09:48Z","timestamp":1790140188816,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T00:00:00Z","timestamp":1390262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>The monocytic leukemia zinc finger protein <jats:italic>KAT6A<\/jats:italic> (formerly <jats:italic>MOZ<\/jats:italic>) gene is recurrently rearranged by chromosomal translocations in acute myeloid leukemia (AML). <jats:italic>KAT6A<\/jats:italic> is known to be fused to several genes, all of which have histone acetyltransferase (HAT) activity and interact with a number of transcription factors as a transcriptional coactivator. The present study shows that the leucine twenty homeobox (<jats:italic>LEUTX<\/jats:italic>) gene on 19q13 is fused to the <jats:italic>KAT6A<\/jats:italic> gene on 8p11 in a therapy\u2010related AML with t(8;19)(p11;q13) using the cDNA bubble PCR method. The fusion transcripts contained 83 nucleotides upstream of the first ATG of <jats:italic>LEUTX<\/jats:italic> and are presumed to create in\u2010frame fusion proteins. <jats:italic>LEUTX<\/jats:italic> is known to have a homeobox domain. Expression of the <jats:italic>LEUTX<\/jats:italic> gene was only detected in placenta RNA by RT\u2010PCR, but not in any tissues by Northern blot analysis. The putative LEUTX protein does not contain any HAT domain, and this is the first study to report that <jats:italic>KAT6A<\/jats:italic> can fuse to the homeobox gene. The current study, with identification of a new partner gene to <jats:italic>KAT6A<\/jats:italic> in a therapy\u2010related AML, does not elucidate the mechanisms of leukemogenesis in <jats:italic>KAT6A\u2010<\/jats:italic>related AML but describes a new gene with a different putative function. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.22140","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T05:39:23Z","timestamp":1390282763000},"page":"299-308","source":"Crossref","is-referenced-by-count":24,"title":["The leucine twenty homeobox (<i>LEUTX<\/i>) gene, which lacks a histone acetyltransferase domain, is fused to <i>KAT6A<\/i> in therapy\u2010related acute myeloid leukemia with t(8;19)(p11;q13)"],"prefix":"10.1002","volume":"53","author":[{"given":"Yoshiaki","family":"Chinen","sequence":"first","affiliation":[{"name":"Department of Molecular Hematology and Oncology Kyoto Prefectural University of Medicine Graduate School of 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