{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T10:29:11Z","timestamp":1789813751678,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,4,12]],"date-time":"2014-04-12T00:00:00Z","timestamp":1397260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>Multiple myeloma (MM) is a malignant B\u2010cell neoplasm characterized by an uncontrolled proliferation of aberrant plasma cells in the bone marrow. Chromosome aberrations in MM are complex and represent a hallmark of the disease, involving many chromosomes that are altered both numerically and structurally. Nearly half of the cases are nonhyperdiploid and show <jats:italic>IGH<\/jats:italic> translocations with the following partner genes: <jats:italic>CCND1<\/jats:italic>, <jats:italic>FGFR3<\/jats:italic> and <jats:italic>MMSET<\/jats:italic>, <jats:italic>MAF<\/jats:italic>, <jats:italic>MAFB<\/jats:italic>, and <jats:italic>CCND3<\/jats:italic>. The remaining 50% are grouped into a hyperdiploid group that is characterized by multiple trisomies involving chromosomes 3, 5, 7, 9, 11, 15, 19, and 21. In this study, we analyzed the immunoglobulin light chain kappa (<jats:italic>IGK<\/jats:italic>, 2p12) and lambda (<jats:italic>IGL<\/jats:italic>, 22q11) loci in 150 cases, mostly with MM but in a few cases monoclonal gammopathy of undetermined significance (MGUS), without <jats:italic>IGH<\/jats:italic> translocations. We identified aberrations in 27% (= 40 patients) including rearrangements (12%), gains (12%), and deletions (4.6%). In 6 of 18 patients with <jats:italic>IGK<\/jats:italic> or\/and <jats:italic>IGL<\/jats:italic> rearrangements, we detected a <jats:italic>MYC<\/jats:italic> rearrangement which suggests that <jats:italic>MYC<\/jats:italic> is the translocation partner in the majority of these cases. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.22175","type":"journal-article","created":{"date-parts":[[2014,4,12]],"date-time":"2014-04-12T07:47:27Z","timestamp":1397288847000},"page":"650-656","source":"Crossref","is-referenced-by-count":8,"title":["High prevalence of immunoglobulin light chain gene aberrations as revealed by FISH in multiple myeloma and MGUS"],"prefix":"10.1002","volume":"53","author":[{"given":"Seval","family":"T\u00fcrkmen","sequence":"first","affiliation":[{"name":"Labor Berlin, Tumorzytogenetik Berlin Germany"},{"name":"Institut f\u00fcr Medizinische Genetik und Humangenetik, Charit\u00e9 CVK Berlin 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