{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:49:06Z","timestamp":1791571746564,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T00:00:00Z","timestamp":1398384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Bundesministerium f\u00fcr Bildung und Forschung (BMBF)","award":["01DL12027"],"award-info":[{"award-number":["01DL12027"]}]},{"DOI":"10.13039\/501100005973","name":"Dr. Mildred Scheel Stiftung f\u00fcr Krebsforschung","doi-asserted-by":"crossref","award":["110822"],"award-info":[{"award-number":["110822"]}],"id":[{"id":"10.13039\/501100005973","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>\n                    Thymic neuroendocrine tumors (TNET) are rare primary epithelial neoplasms of the thymus. This study aimed to determine clinically relevant parameters for their classification and for therapeutic decisions. We performed a comprehensive histological, clinical, and genetic study of 73 TNET cases (13 thymic typical carcinoids [TTC], 40 thymic atypical carcinoids [TAC], and 20 high\u2010grade neuroendocrine carcinomas [HGNEC] of the thymus), contributed by multiple institutions. The mean number of chromosomal imbalances per tumor was 0.8 in TTC (31% aberrant cases) versus 1.1 in TAC (44% aberrant cases) versus 4.7 in HGNEC (75% aberrant cases). Gains of 8q24 (\n                    <jats:italic>MYC<\/jats:italic>\n                    gene locus) were the most frequent alteration and one of the overlapping features between carcinoids and HGNEC. The 5\u2010year survival rates for TTC, TAC, and HGNEC were 100, 60, and 30%. The 10\u2010year survival rates for TTC and TAC were 50 and 30% (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.002). Predictive mitotic cut\u2010off values for TTC versus TAC were 2.5 per 10 high\u2010power fields (HPF; indicating a higher death rate,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.062) and 15 per 10 HPF (indicating higher risk of recurrence,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.036) for separating HGNEC from TAC. We conclude that the current histopathologic classifications of TNET reflect tumor biology and provide important information for therapeutic management. \u00a9 2014 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/gcc.22183","type":"journal-article","created":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T03:22:05Z","timestamp":1398396125000},"page":"738-749","source":"Crossref","is-referenced-by-count":66,"title":["Tumor genetics and survival of thymic neuroendocrine neoplasms: A multi\u2010institutional clinicopathologic study"],"prefix":"10.1002","volume":"53","author":[{"given":"Philipp","family":"Str\u00f6bel","sequence":"first","affiliation":[{"name":"Institute of Pathology, University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Zettl","sequence":"additional","affiliation":[{"name":"Institute of Pathologie Viollier Basle Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Shilo","sequence":"additional","affiliation":[{"name":"Department of Pathology Ohio State University Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Yu","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Pathology Chang Gung Memorial Hospital and Chang Gung University Linkou Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Department of Histopathology Royal Brompton and Harefield NHS Foundation Trust and National Heart and Lung Institute Imperial College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Matsuno","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Hokkaido University Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Gal","sequence":"additional","affiliation":[{"name":"Pathology &amp; Laboratory Medicine Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf Hubert","family":"Laeng","sequence":"additional","affiliation":[{"name":"Pathologie L\u00e4nggasse Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Pathology Roskilde Hospital Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Capella","sequence":"additional","affiliation":[{"name":"Department of Human Morphology Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Pathology Regina Elena National Cancer Institute Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Kwok-Cheung","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pathology Queen Elizabeth Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Rosenwald","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University of W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Travis","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teri J.","family":"Franks","sequence":"additional","affiliation":[{"name":"Pulmonary &amp; 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