{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:37:48Z","timestamp":1789983468582,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T00:00:00Z","timestamp":1404777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01KU1002A to 01KU1002J and 0316166B"],"award-info":[{"award-number":["01KU1002A to 01KU1002J and 0316166B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dr. Werner Jackst\u00ef\u00bf\u00bddt Foundation","award":["S134 - 10.100"],"award-info":[{"award-number":["S134 - 10.100"]}]},{"name":"Forschungshilfe Peiper"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>\n                    Burkitt lymphoma (BL) is the most frequent B\u2010cell lymphoma in childhood. Genetically, it is characterized by the presence of an\n                    <jats:italic>IG\u2010MYC<\/jats:italic>\n                    translocation which is supposed to be an initiating but not sufficient event in Burkitt lymphomagenesis. In a recent whole\u2010genome sequencing study of four cases, we showed that the gene encoding the ras homolog family member A (\n                    <jats:italic>RHOA<\/jats:italic>\n                    ) is recurrently mutated in pediatric BL. Here, we analyzed\n                    <jats:italic>RHOA<\/jats:italic>\n                    by Sanger sequencing in a cohort of 101 pediatric B\u2010cell lymphoma patients treated according to Non\u2010Hodgkin's Lymphoma Berlin\u2013Frankfurt\u2013M\u00fcnster (NHL\u2010BFM) study protocols. Among the 78 BLs in this series, an additional five had\n                    <jats:italic>RHOA<\/jats:italic>\n                    mutations resulting in a total incidence of 7\/82 (8.5%) with c.14G&gt;A (p.R5Q) being present in three cases. Modeling the mutational effect suggests that most of them inactivate the RHOA protein. Thus, deregulation of RHOA by mutation is a recurrent event in Burkitt lymphomagenesis in children. \u00a9 2014 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/gcc.22202","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T02:37:07Z","timestamp":1404787027000},"page":"911-916","source":"Crossref","is-referenced-by-count":56,"title":["Recurrent\n                    <i>RHOA<\/i>\n                    mutations in pediatric\n                    <scp>B<\/scp>\n                    urkitt lymphoma treated according to the NHL\u2010BFM protocols"],"prefix":"10.1002","volume":"53","author":[{"given":"Marius","family":"Rohde","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University Hospital Giessen Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Richter","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Christian\u2010Albrechts\u2010University Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schlesner","sequence":"additional","affiliation":[{"name":"Division Theoretical Bioinformatics Deutsches Krebsforschungszentrum Heidelberg (DKFZ) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Betts","sequence":"additional","affiliation":[{"name":"Cell Networks, Bioquant University of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Claviez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital Schleswig\u2010Holstein Campus Kiel Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina R.","family":"Bonn","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University Hospital Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University Hospital Giessen Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Damm\u2010Welk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University Hospital Giessen Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Russell","sequence":"additional","affiliation":[{"name":"Cell Networks, Bioquant University of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt","family":"Borkhardt","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hematology and Clinical Immunology Heinrich\u2010Heine\u2010University D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Eils","sequence":"additional","affiliation":[{"name":"Division Theoretical Bioinformatics Deutsches Krebsforschungszentrum Heidelberg (DKFZ) Heidelberg Germany"},{"name":"Department for Bioinformatics and Functional Genomics Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica I.","family":"Hoell","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hematology and Clinical Immunology Heinrich\u2010Heine\u2010University D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Szczepanowski","sequence":"additional","affiliation":[{"name":"Hematopathology Section Christian\u2010Albrechts\u2010University Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilske","family":"Oschlies","sequence":"additional","affiliation":[{"name":"Hematopathology Section Christian\u2010Albrechts\u2010University Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Klapper","sequence":"additional","affiliation":[{"name":"Hematopathology Section Christian\u2010Albrechts\u2010University Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University Hospital Giessen Giessen Germany"},{"name":"Department of Pediatric Hematology and Oncology University Hospital Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Siebert","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Christian\u2010Albrechts\u2010University Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the German ICGC MMML\u2010Seq\u2010Project and the NHL\u2010BFM Study 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