{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:18:14Z","timestamp":1790389094941,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,18]],"date-time":"2014-09-18T00:00:00Z","timestamp":1410998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50"],"award-info":[{"award-number":["P50"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>\n                    Sclerosing epithelioid fibrosarcoma (SEF) is a rare soft tissue tumor exhibiting considerable morphologic overlap with low\u2010grade fibromyxoid sarcoma (LGFMS). Moreover, both SEF and LGFMS show MUC4 expression by immunohistochemistry. While the majority of LGFMS cases are characterized by a\n                    <jats:italic>FUS\u2010CREB3L1<\/jats:italic>\n                    fusion, both\n                    <jats:italic>FUS\u2010CREB3L2<\/jats:italic>\n                    and\n                    <jats:italic>EWSR1\u2010CREB3L1<\/jats:italic>\n                    fusions were recently demonstrated in a small number of LGFMS and SEF\/LGFMS hybrid tumors. In contrast, recent studies pointed out that SEF harbor frequent\n                    <jats:italic>EWSR1<\/jats:italic>\n                    rearrangements, with only a minority of cases showing\n                    <jats:italic>FUS\u2010CREB3L2<\/jats:italic>\n                    fusions. In an effort to further characterize the molecular characteristics of pure SEF and hybrid SEF\/LGFMS lesions, we undertook a clinicopathologic, immunohistochemical and genetic analysis of a series of 10 SEF and 8 hybrid SEF\/LGFMS tumors. The mortality rate was similar between the two groups, 44% within the pure SEF group and 37% in the hybrid SEF\/LGFMS with a mean overall follow\u2010up of 66 months. All but one pure SEF and all hybrid SEF\/LGFMS\u2010tested cases showed MUC4 immunoreactivity. The majority (90%) of pure SEF cases showed\n                    <jats:italic>EWSR1<\/jats:italic>\n                    gene rearrangements by fluorescence in situ hybridization with only one case exhibiting\n                    <jats:italic>FUS<\/jats:italic>\n                    rearrangement. Of the nine\n                    <jats:italic>EWSR1<\/jats:italic>\n                    positive cases, six cases harbored\n                    <jats:italic>CREB3L1<\/jats:italic>\n                    break\u2010apart, two had\n                    <jats:italic>CREB3L2<\/jats:italic>\n                    rearrangement (a previously unreported finding) and one lacked evidence of\n                    <jats:italic>CREB3L1\/2<\/jats:italic>\n                    abnormalities. In contrast, all hybrid SEF\/LGFMS tumors exhibited\n                    <jats:italic>FUS<\/jats:italic>\n                    and\n                    <jats:italic>CREB3L2<\/jats:italic>\n                    rearrangements. These results further demarcate a relative cytogenetic dichotomy between pure SEF, often characterized by\n                    <jats:italic>EWSR1<\/jats:italic>\n                    rearrangements, and hybrid SEF\/LGFMS, harboring\n                    <jats:italic>FUS\u2010CREB3L2<\/jats:italic>\n                    fusion; the latter group recapitulating the genotype of LGFMS. \u00a9 2014 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/gcc.22215","type":"journal-article","created":{"date-parts":[[2014,9,18]],"date-time":"2014-09-18T02:41:16Z","timestamp":1411008076000},"page":"28-38","source":"Crossref","is-referenced-by-count":102,"title":["A genetic dichotomy between pure sclerosing epithelioid fibrosarcoma (SEF) and hybrid SEF\/low\u2010grade fibromyxoid sarcoma: A pathologic and molecular study of 18 cases"],"prefix":"10.1002","volume":"54","author":[{"given":"Carlos","family":"Prieto\u2010Granada","sequence":"first","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao\u2010Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Shao","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narasimhan P","family":"Agaram","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim A","family":"Jungbluth","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina R","family":"Antonescu","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0000000000000049"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200106000-00001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20819"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20897"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000158"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000979"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3135"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.87"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00882.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.3.1489"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199601)15:1<73::AID-GCC10>3.0.CO;2-Q"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/359162a0"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182a05a6b"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318210c268"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182562bf8"},{"key":"e_1_2_5_18_1","first-page":"615","article-title":"Low\u2010grade fibromyxoid sarcoma","volume":"88","author":"Evans HL","year":"1987","journal-title":"A report of two metastasizing neoplasms having a deceptively benign appearance. 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