{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:21:41Z","timestamp":1784953301454,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T00:00:00Z","timestamp":1411430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["2011-294576"],"award-info":[{"award-number":["2011-294576"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN 2012\/741"],"award-info":[{"award-number":["CAN 2012\/741"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003252","name":"Lunds Universitet","doi-asserted-by":"publisher","award":["Doktorandm\u00c3\u00a5nader"],"award-info":[{"award-number":["Doktorandm\u00c3\u00a5nader"]}],"id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Three studies have reported that <jats:italic>BRCA1\/2<\/jats:italic> mutations of paternal origin confer an earlier age at breast cancer diagnosis compared with maternal origin. The primary aim of this study was to investigate the impact of parental origin of <jats:italic>BRCA1\/2<\/jats:italic> mutations on age at breast and ovarian cancer diagnosis. This study included 577 female <jats:italic>BRCA1\/2<\/jats:italic> mutation carriers. All <jats:italic>BRCA1\/2<\/jats:italic> mutation carriers belonged to families registered between 1993 and 2011 at the Oncogenetic Clinic at Sk\u00e5nes University Hospital, Lund, Sweden. Cox proportional hazard ratios were used to analyze time to breast or ovarian cancer diagnosis. A novel finding was that carriers of <jats:italic>BRCA1<\/jats:italic> mutations of paternal origin were 4 years older at age of ovarian cancer (<jats:italic>P<\/jats:italic> = 0.009) compared with those carrying a <jats:italic>BRCA1<\/jats:italic> mutation of maternal origin. <jats:italic>BRCA1<\/jats:italic> carriers with mutations of paternal origin were 4 years younger at breast cancer diagnosis (<jats:italic>P<\/jats:italic> = 0.017) compared with those carrying a <jats:italic>BRCA1<\/jats:italic> mutation of maternal origin, which is in agreement with three previous studies. Both findings were adjusted for of year of inclusion, birth date, and oral contraceptive pill use. No associations between parental origin of <jats:italic>BRCA2<\/jats:italic> mutations and time to breast or ovarian cancer diagnosis were found. An attempt to handle a potential selection bias regarding use of oral contraceptives was made using multiple imputations by chained equations. The observed age difference may allow a greater understanding of mechanisms associated with the differences in cancer penetrance in <jats:italic>BRCA1\/2<\/jats:italic> mutation carriers, some of which may depend on paternal origin. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.22217","type":"journal-article","created":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T03:55:25Z","timestamp":1411530925000},"page":"39-50","source":"Crossref","is-referenced-by-count":7,"title":["Impact of a paternal origin of germline <i>BRCA1<\/i>\/2 mutations on the age at breast and ovarian cancer diagnosis in a Southern Swedish cohort"],"prefix":"10.1002","volume":"54","author":[{"given":"Carolina","family":"Ellberg","sequence":"first","affiliation":[{"name":"Division of Oncology and Pathology, Department of Clinical Sciences Lund Lund University, Sk\u00e5ne University Hospital Lund Sweden"},{"name":"Division of Cancer Epidemiology, Department of Clinical Sciences Lund Lund 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