{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:47:54Z","timestamp":1761101274640},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T00:00:00Z","timestamp":1433548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the National R&D Program for Cancer Control, Ministry for Health and Welfare, Republic of Korea","award":["1020370"],"award-info":[{"award-number":["1020370"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>According to recent guidelines, cytogenetically normal acute myeloid leukemia (CN AML) is divided into four molecular subgroups based on nucleophosmin\u20101 (<jats:italic>NPM1<\/jats:italic>) and FMS\u2010like tyrosine kinase 3\u2010internal tandem duplication (<jats:italic>FLT3\u2010<\/jats:italic>ITD) mutations. All subgroups except for isolated <jats:italic>NPM1<\/jats:italic>mut are associated with poor prognosis. We retrospectively analyzed 223 patients with CN AML, 156 of whom were treated with standard chemotherapy. For postremission therapy, patients with available donors underwent allogeneic (allo) hematopoietic stem cell transplantation (HSCT) and the rest were treated with autologous HSCT or chemotherapy alone. We first compared the 4 conventional molecular subgroups, and then created another 4 subgroups based on <jats:italic>WT1<\/jats:italic> expression: isolated <jats:italic>NPM1<\/jats:italic>mut, <jats:italic>NPM1<\/jats:italic>wt\/<jats:italic>FLT3\u2010<\/jats:italic>ITD<jats:italic>\u2010<\/jats:italic>neg with low <jats:italic>WT1<\/jats:italic> or high <jats:italic>WT1<\/jats:italic>, and <jats:italic>FLT3\u2010<\/jats:italic>ITD<jats:italic>\u2010<\/jats:italic>pos CN AML. We finally evaluated 89 patients who were treated with allo HSCT and achieved complete remission after standard chemotherapy. <jats:italic>FLT3\u2010<\/jats:italic>ITD CN AML showed the worst outcome irrespective of <jats:italic>NPM1<\/jats:italic>mut, and isolated <jats:italic>NPM1<\/jats:italic>mut CN AML showed no significant differences compared with <jats:italic>NPM1<\/jats:italic>wt\/<jats:italic>FLT3\u2010<\/jats:italic>ITD<jats:italic>\u2010<\/jats:italic>neg CN AML. In contrast, two newly stratified low\u2010risk subgroups (<jats:italic>NPM1<\/jats:italic>wt\/<jats:italic>FLT3\u2010<\/jats:italic>ITD<jats:italic>\u2010<\/jats:italic>neg with low <jats:italic>WT1<\/jats:italic> and isolated <jats:italic>NPM1<\/jats:italic>mut CN AML) showed higher remission rates with superior overall survival (OS) compared with the other two high\u2010risk subgroups, which showed a higher relapse rate even after allo HSCT. Further analysis showed that higher pre\u2010HSCT expression of <jats:italic>WT1<\/jats:italic> resulted in a higher relapse rate and poorer OS after allo HSCT. For CN AML, a risk\u2010adapted approach using allo HSCT with novel agents should be evaluated with stratification specified by <jats:italic>WT1<\/jats:italic>. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.22260","type":"journal-article","created":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T13:30:09Z","timestamp":1433597409000},"page":"489-499","source":"Crossref","is-referenced-by-count":10,"title":["Outcome of allogeneic hematopoietic stem cell transplantation for cytogenetically normal <scp>AML<\/scp> and identification of high\u2010risk subgroup using <scp><i>W<\/i><\/scp><i>T1<\/i> expression in association with <scp><i>N<\/i><\/scp><i>PM1<\/i> and <scp><i>FLT3\u2010<\/i>ITD<\/scp> mutations"],"prefix":"10.1002","volume":"54","author":[{"given":"Jae\u2010Ho","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Hematology, Catholic Blood and Marrow Transplantation Center Cancer Research Institute, Seoul St. Mary's Hospital, the 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