{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:14:06Z","timestamp":1789874046673,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:00:00Z","timestamp":1442880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Supported by: National Cancer Center Research and Development Fund of Japan","award":["23-A-17; Grant-in-Aid of Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan"],"award-info":[{"award-number":["23-A-17; Grant-in-Aid of Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>The deleted in colorectal carcinoma <jats:italic>(DCC)<\/jats:italic> gene at 18q21 encodes a netrin\u20101 receptor, a tumor suppressor that prevents cell growth. While allele loss or decreased expression of <jats:italic>DCC<\/jats:italic> has been associated with the progression of solid tumors and hematologic malignancies, including leukemias and malignant lymphomas, its involvement has not been evaluated in multiple myeloma (MM), a plasma cell malignancy characterized by complex and heterogenous molecular abnormalities. We here show that 10 of 11 human myeloma\u2010derived cell lines (HMCLs) expressed non\u2010translated aberrant <jats:italic>DCC<\/jats:italic> transcriptional variants, in which exon 2 fuses with intron 1 instead of exon 1 (<jats:italic>mt.DCC<\/jats:italic>). Among them, two co\u2010expressed wild type transcripts (<jats:italic>wt.DCC<\/jats:italic>), while eight co\u2010expressed the splicing variant (<jats:italic>sv.DCC<\/jats:italic>) lacking exon 1. The remaining HMCL expressed only <jats:italic>sv.DCC<\/jats:italic>. In addition, analyses revealed that there were two types of <jats:italic>mt.DCC<\/jats:italic> that differed in their fusion of intron 1 with exon 2. In patient\u2010derived samples from 30 MM and 8 monoclonal gammopathy of undetermined significance (MGUS) patients, <jats:italic>wt.DCC<\/jats:italic> was expressed in 53% of MM, but not in MGUS, while 23% of MM and 75% of MGUS expressed only <jats:italic>sv.DCC<\/jats:italic>. Considering that 25% of MGUS, 57% of MM, and 91% HMCLs expressed <jats:italic>mt.DCC<\/jats:italic>, our results suggest that the acquisition of <jats:italic>mt.DCC<\/jats:italic> might be a secondary genetic change in plasma cell dyscrasia. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.22290","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T07:00:46Z","timestamp":1442905246000},"page":"788-795","source":"Crossref","is-referenced-by-count":6,"title":["Transcriptional dysregulation of the deleted in colorectal carcinoma gene in multiple myeloma and monoclonal gammopathy of undetermined significance"],"prefix":"10.1002","volume":"54","author":[{"given":"Hisao","family":"Nagoshi","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine, Kyoto Prefectural University of Medicine  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Taki","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostics and Therapeutics Kyoto Prefectural University of Medicine  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Chinen","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine, Kyoto Prefectural University of Medicine  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Tatekawa","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine, Kyoto Prefectural University of Medicine  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine, Kyoto Prefectural University of Medicine  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of Hematology and Oncology Department of Medicine, Kyoto Prefectural University of Medicine  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine, Kyoto Prefectural University of Medicine  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Horiike","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine, Kyoto Prefectural University of Medicine  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Okuno","sequence":"additional","affiliation":[{"name":"Department of Hematology Kumamoto University School of Medicine  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Hematology Kumamoto University School of Medicine  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Hata","sequence":"additional","affiliation":[{"name":"Division of Informative Clinical Science Kumamoto University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine, Kyoto Prefectural University of Medicine  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Taniwaki","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine, Kyoto Prefectural University of Medicine  Japan"},{"name":"Department of Molecular Diagnostics and Therapeutics Kyoto Prefectural University of Medicine  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