{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:12:59Z","timestamp":1762866779834},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000032","name":"Institute of Infection and Immunity","doi-asserted-by":"publisher","award":["PI 11\/02010","PI\/14\/00013"],"award-info":[{"award-number":["PI 11\/02010","PI\/14\/00013"]}],"id":[{"id":"10.13039\/501100000032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004141","name":"Society of Gastrointestinal Radiologists","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006436","name":"Celgene","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006436","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>Chromosomal translocations are rare in the myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML). With the exception of t(3q), translocations are not explicitly considered in the cytogenetic classification of the IPSS\u2010R and their impact on disease progression and patient survival is unknown. The present study was aimed at determining the prognostic impact of translocations in the context of the cytogenetic classification of the IPSS\u2010R. We evaluated 1,653 patients from the Spanish Registry of MDS diagnosed with MDS or CMML and an abnormal karyotype by conventional cytogenetic analysis. Translocations were identified in 168 patients (T group). Compared with the 1,485 patients with abnormal karyotype without translocations (non\u2010T group), the T group had a larger proportion of patients with refractory anemia with excess of blasts and higher scores in both the cytogenetic and global IPSS\u2010R. Translocations were associated with a significantly shorter survival and higher incidence of transformation into AML at univariate analysis but both features disapeared after multivariate adjustment for the IPSS\u2010R cytogenetic category. Patients with single or double translocations other than t(3q) had an outcome similar to those in the non\u2010T group in the intermediate cytogenetic risk category of the IPSS\u2010R. In conclusion, the presence of translocations identifies a subgroup of MDS\/CMML patients with a more aggressive clinical presentation that can be explained by a higher incidence of complex karyotypes. Single or double translocations other than t(3q) should be explicitly considered into the intermediate risk category of cytogenetic IPSS\u2010R classification. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.22333","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T11:55:23Z","timestamp":1450785323000},"page":"322-327","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic impact of chromosomal translocations in myelodysplastic syndromes and chronic myelomonocytic leukemia patients. A study by the spanish group of myelodysplastic syndromes"],"prefix":"10.1002","volume":"55","author":[{"given":"Meritxell","family":"Nomdedeu","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednic Barcelona Spain"},{"name":"Fundaci\u00f3 Cl\u00ednic per la Recerca Biom\u00e8dica Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Calvo","sequence":"additional","affiliation":[{"name":"Hospital del Mar, IMIM (Institut Hospital del Mar d'lnvestigacions M\u00e8diques) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Pereira","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Carri\u00f3","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesc","family":"Sol\u00e9","sequence":"additional","affiliation":[{"name":"Josep Carreras Leukemia Research Institue, Campus ICO Badalona Spain"},{"name":"ICO\u2010 Hospital Germans Trias i Pujol UAB, Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Lu\u00f1o","sequence":"additional","affiliation":[{"name":"Hospital Central Universitario de Asturias Oviedo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Cervera","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Fe Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Vallesp\u00ed","sequence":"additional","affiliation":[{"name":"Hospital Vall d'Hebr\u00f3n Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concha","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e1ndida","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amparo","family":"Arias","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esperanza","family":"Such","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Fe Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Sanz","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Fe Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Grau","sequence":"additional","affiliation":[{"name":"ICO\u2010 Hospital Germans Trias i Pujol UAB, Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Insunza","sequence":"additional","affiliation":[{"name":"Hospital Marqu\u00e9s de Valdecilla Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda\u2010Jos\u00e9","family":"Calasanz","sequence":"additional","affiliation":[{"name":"Universidad de Navarra Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda\u2010Teresa","family":"Ardanaz","sequence":"additional","affiliation":[{"name":"Hospital Txagorritxu Vitoria Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas\u2010Mar\u00eda","family":"Hern\u00e1ndez\u2010Rivas","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Salamanca Salamanca Spain"},{"name":"IBSAL, University of Salamanca Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Azaceta","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Zaragoza Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Oncol\u00f3gicas Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Hospital Reina Sof\u00eda C\u00f3rdoba Spain"},{"name":"IMIBIC, University of C\u00f3rdoba Cordoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda\u2010Luisa","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Hospital Doce de Octubre Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Bargay","sequence":"additional","affiliation":[{"name":"Hospital Son Ll\u00e0tzer Mallorca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valle","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La Princesa Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos\u2010Javier","family":"Cervero","sequence":"additional","affiliation":[{"name":"Hospital Virgen de la Luz Cuenca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda\u2010Jos\u00e9","family":"Allegue","sequence":"additional","affiliation":[{"name":"Complexo Hospitalario de Pontevedra Pontevedra Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Collado","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Valencia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u00edas","family":"Campo","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Esteve","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benet","family":"Nomdedeu","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolors","family":"Costa","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the Spanish Group of Myelodysplastic Syndromes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2015.03.017"},{"key":"e_1_2_6_3_1","first-page":"101","article-title":"Cumulative incidence estimation in the presence of competing risks","volume":"4","author":"Boggess M","year":"2004","journal-title":"Stata"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2009.07.006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22071"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-235358"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2089"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/81.3.515"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.6.2079"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-420489"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-008-0483-y"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.87"},{"key":"e_1_2_6_14_1","first-page":"1315","article-title":"Cytogenetic analysis has strong independent prognostic value in de novo myelodysplastic syndromes and can be incorporated in a new scoring system: A report on 408 cases","volume":"7","author":"Morel P","year":"1993","journal-title":"Leukemia"},{"volume-title":"An International System for Human Cytogenetic Nomenclature","year":"2013","author":"Schaffer LG","key":"e_1_2_6_15_1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.6394"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0902908"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.22333","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.22333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T14:40:50Z","timestamp":1696603250000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.22333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,22]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/gcc.22333"],"URL":"https:\/\/doi.org\/10.1002\/gcc.22333","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"type":"print","value":"1045-2257"},{"type":"electronic","value":"1098-2264"}],"subject":[],"published":{"date-parts":[[2015,12,22]]}}}